Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

Wenbo Hu, Hengheng Ma, Bing Hou, Hui Zhao, Yu Ji, Rongcui Jiang, Xiaoming Hu, Xiaomei Lu, Lei Zhang, Yufu Tang, Quli Fan, Wei Huang

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131 引用 (Scopus)

摘要

Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against cancer cells under NIR light.

源语言英语
页(从-至)12039-12047
页数9
期刊ACS Applied Materials and Interfaces
8
19
DOI
出版状态已出版 - 18 5月 2016

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