Fully automated continuous meso-flow synthesis of 5′-nucleotides and deoxynucleotides

Chenjie Zhu; Chenglun Tang; Zhi Cao; Wei He; Yong Chen; Xiaochun Chen; Kai Guo; Hanjie Ying

doi:10.1021/op5002066

Fully automated continuous meso-flow synthesis of 5′-nucleotides and deoxynucleotides

Chenjie Zhu, Chenglun Tang, Zhi Cao, Wei He, Yong Chen, Xiaochun Chen, Kai Guo, Hanjie Ying

生物与制药工程学院

科研成果: 期刊稿件 › 文章 › 同行评审

8 引用（Scopus）

摘要

The first continuous meso-flow synthesis of natural and non-natural 5′-nucleotides and deoxynucleotides is described, representing a significant advance over the corresponding in-flask method. By means of this meso-flow technique, a synthesis with time consumption and high-energy consumption becomes facile to generate products with great efficiency. An abbreviated duration, satisfactory output, and mild reaction conditions are expected to be realized under the present procedure.

源语言	英语
页（从-至）	1575-1581
页数	7
期刊	Organic Process Research and Development
卷	18
期	11
DOI	https://doi.org/10.1021/op5002066
出版状态	已出版 - 21 11月 2014

联合国可持续发展目标

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10.1021/op5002066

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abstract = "The first continuous meso-flow synthesis of natural and non-natural 5′-nucleotides and deoxynucleotides is described, representing a significant advance over the corresponding in-flask method. By means of this meso-flow technique, a synthesis with time consumption and high-energy consumption becomes facile to generate products with great efficiency. An abbreviated duration, satisfactory output, and mild reaction conditions are expected to be realized under the present procedure.",

author = "Chenjie Zhu and Chenglun Tang and Zhi Cao and Wei He and Yong Chen and Xiaochun Chen and Kai Guo and Hanjie Ying",

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T1 - Fully automated continuous meso-flow synthesis of 5′-nucleotides and deoxynucleotides

AU - Zhu, Chenjie

AU - Tang, Chenglun

AU - Cao, Zhi

AU - He, Wei

AU - Chen, Yong

AU - Chen, Xiaochun

AU - Guo, Kai

AU - Ying, Hanjie

PY - 2014/11/21

Y1 - 2014/11/21

N2 - The first continuous meso-flow synthesis of natural and non-natural 5′-nucleotides and deoxynucleotides is described, representing a significant advance over the corresponding in-flask method. By means of this meso-flow technique, a synthesis with time consumption and high-energy consumption becomes facile to generate products with great efficiency. An abbreviated duration, satisfactory output, and mild reaction conditions are expected to be realized under the present procedure.

AB - The first continuous meso-flow synthesis of natural and non-natural 5′-nucleotides and deoxynucleotides is described, representing a significant advance over the corresponding in-flask method. By means of this meso-flow technique, a synthesis with time consumption and high-energy consumption becomes facile to generate products with great efficiency. An abbreviated duration, satisfactory output, and mild reaction conditions are expected to be realized under the present procedure.

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M3 - 文章

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SN - 1083-6160

VL - 18

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EP - 1581

JO - Organic Process Research and Development

JF - Organic Process Research and Development

IS - 11

ER -

Fully automated continuous meso-flow synthesis of 5′-nucleotides and deoxynucleotides

摘要

联合国可持续发展目标

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