Generation of Oxazolidine-2,4-diones Bearing Sulfur-Substituted Quaternary Carbon Atoms by Oxothiolation/Cyclization of Ynamides

Hai Huang, Junzhen Fan, Guangke He, Zhimin Yang, Xiaodong Jin, Qi Liu, Hongjun Zhu

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21 引用 (Scopus)

摘要

A novel method for metal-free oxothiolation of ynamides to construct oxazolidine-2,4-diones bearing sulfur-substituted quaternary carbon atoms has been developed. It represents a rare C-O bond cleavage of ynamides, as well as a facile and tandem approach for the formation of C-O, C-S, and C-Cl bonds. This redox-neutral protocol can be applied to the synthesis of multisubstituted oxazolidine-2,4-diones with good chemoselectivity and good yields of isolated products under mild conditions.

源语言英语
页(从-至)2532-2538
页数7
期刊Chemistry - A European Journal
22
7
DOI
出版状态已出版 - 12 2月 2016

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