TY - JOUR
T1 - Genetic tool development and systemic regulation in biosynthetic technology
AU - Dai, Zhongxue
AU - Zhang, Shangjie
AU - Yang, Qiao
AU - Zhang, Wenming
AU - Qian, Xiujuan
AU - Dong, Weiliang
AU - Jiang, Min
AU - Xin, Fengxue
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/6/1
Y1 - 2018/6/1
N2 - With the increased development in research, innovation, and policy interest in recent years, biosynthetic technology has developed rapidly, which combines engineering, electronics, computer science, mathematics, and other disciplines based on classical genetic engineering and metabolic engineering. It gives a wider perspective and a deeper level to perceive the nature of life via cell mechanism, regulatory networks, or biological evolution. Currently, synthetic biology has made great breakthrough in energy, chemical industry, and medicine industries, particularly in the programmable genetic control at multiple levels of regulation to perform designed goals. In this review, the most advanced and comprehensive developments achieved in biosynthetic technology were represented, including genetic engineering as well as synthetic genomics. In addition, the superiority together with the limitations of the current genome-editing tools were summarized.
AB - With the increased development in research, innovation, and policy interest in recent years, biosynthetic technology has developed rapidly, which combines engineering, electronics, computer science, mathematics, and other disciplines based on classical genetic engineering and metabolic engineering. It gives a wider perspective and a deeper level to perceive the nature of life via cell mechanism, regulatory networks, or biological evolution. Currently, synthetic biology has made great breakthrough in energy, chemical industry, and medicine industries, particularly in the programmable genetic control at multiple levels of regulation to perform designed goals. In this review, the most advanced and comprehensive developments achieved in biosynthetic technology were represented, including genetic engineering as well as synthetic genomics. In addition, the superiority together with the limitations of the current genome-editing tools were summarized.
KW - Genetic engineering
KW - Genetic tools
KW - Synthetic biology
KW - Synthetic genomics
UR - http://www.scopus.com/inward/record.url?scp=85048247939&partnerID=8YFLogxK
U2 - 10.1186/s13068-018-1153-5
DO - 10.1186/s13068-018-1153-5
M3 - 文献综述
AN - SCOPUS:85048247939
SN - 1754-6834
VL - 11
JO - Biotechnology for Biofuels
JF - Biotechnology for Biofuels
IS - 1
M1 - 152
ER -