Highly enantioselective ketone-ene reactions of trifluoropyruvate: Significant counterion effect of the in(III)-pybox complex

Jun Feng Zhao; Teguh Budiono W. Tjan; Boon Hong Tan; Teck Peng Loh

doi:10.1021/ol902507x

Highly enantioselective ketone-ene reactions of trifluoropyruvate: Significant counterion effect of the in(III)-pybox complex

Jun Feng Zhao, Teguh Budiono W. Tjan, Boon Hong Tan, Teck Peng Loh

Nanyang Technological University

科研成果: 期刊稿件 › 文章 › 同行评审

38 引用（Scopus）

摘要

[Chemical Equation Presented] A chiral indium(III)-pybox complex catalyzed asymmetric ketone-ene reaction of trifluoropyruvate is described. Both aromatic and aliphatic 1,1-disubstituted alkenes reacted smoothly to give the enantioenriched tertiary homoallylic alcohols in good to excellent yields (up to 99%) and with excellent enantioselectivities (up to 98% ee).

源语言	英语
页（从-至）	5714-5716
页数	3
期刊	Organic Letters
卷	11
期	24
DOI	https://doi.org/10.1021/ol902507x
出版状态	已出版 - 17 12月 2009
已对外发布	是

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abstract = "[Chemical Equation Presented] A chiral indium(III)-pybox complex catalyzed asymmetric ketone-ene reaction of trifluoropyruvate is described. Both aromatic and aliphatic 1,1-disubstituted alkenes reacted smoothly to give the enantioenriched tertiary homoallylic alcohols in good to excellent yields (up to 99%) and with excellent enantioselectivities (up to 98% ee).",

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AU - Tan, Boon Hong

AU - Loh, Teck Peng

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N2 - [Chemical Equation Presented] A chiral indium(III)-pybox complex catalyzed asymmetric ketone-ene reaction of trifluoropyruvate is described. Both aromatic and aliphatic 1,1-disubstituted alkenes reacted smoothly to give the enantioenriched tertiary homoallylic alcohols in good to excellent yields (up to 99%) and with excellent enantioselectivities (up to 98% ee).

AB - [Chemical Equation Presented] A chiral indium(III)-pybox complex catalyzed asymmetric ketone-ene reaction of trifluoropyruvate is described. Both aromatic and aliphatic 1,1-disubstituted alkenes reacted smoothly to give the enantioenriched tertiary homoallylic alcohols in good to excellent yields (up to 99%) and with excellent enantioselectivities (up to 98% ee).

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Highly enantioselective ketone-ene reactions of trifluoropyruvate: Significant counterion effect of the in(III)-pybox complex

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