Hypervalent Iodine Mediated Synthesis of 2-Aminobenzazoles and 2-Aminobenzothiazoles

Yi Gu; Yao Dong Li; Ye Ge; Jiang Long Huang; Hua Jin Xu; Yi Hu

doi:10.1002/ajoc.202400076

Hypervalent Iodine Mediated Synthesis of 2-Aminobenzazoles and 2-Aminobenzothiazoles

Yi Gu, Yao Dong Li, Ye Ge, Jiang Long Huang, Hua Jin Xu, Yi Hu

药学院

Nanjing Tech University

科研成果: 期刊稿件 › 文章 › 同行评审

2 引用（Scopus）

摘要

The hypervalent iodine mediated, silica gel promoted synthesis of 2-aminobenzazoles and 2-aminobenzothiazole derivatives under metal-free mild conditions within short time (30 min) has been developed. Under this process, PhI(COOCF₃)₂ (PIFA) or PhI(COOCH₃)₂ (PIDA) acts as an oxidant and radical initiator direct activated the ortho-C−H bond of substrate, silica gel as weakly lewis acid effectively increased the reactivity of the reaction system. This method is compatible with various of arylurea and arylthiourea substrates, which is green, efficient, simple to operate and suitable for practical application.

源语言	英语
文章编号	e202400076
期刊	Asian Journal of Organic Chemistry
卷	13
期	6
DOI	https://doi.org/10.1002/ajoc.202400076
出版状态	已出版 - 6月 2024

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title = "Hypervalent Iodine Mediated Synthesis of 2-Aminobenzazoles and 2-Aminobenzothiazoles",

abstract = "The hypervalent iodine mediated, silica gel promoted synthesis of 2-aminobenzazoles and 2-aminobenzothiazole derivatives under metal-free mild conditions within short time (30 min) has been developed. Under this process, PhI(COOCF3)2 (PIFA) or PhI(COOCH3)2 (PIDA) acts as an oxidant and radical initiator direct activated the ortho-C−H bond of substrate, silica gel as weakly lewis acid effectively increased the reactivity of the reaction system. This method is compatible with various of arylurea and arylthiourea substrates, which is green, efficient, simple to operate and suitable for practical application.",

keywords = "Arylurea, cyclization, metal-free",

author = "Yi Gu and Li, \{Yao Dong\} and Ye Ge and Huang, \{Jiang Long\} and Xu, \{Hua Jin\} and Yi Hu",

note = "Publisher Copyright: {\textcopyright} 2024 Wiley-VCH GmbH.",

year = "2024",

month = jun,

doi = "10.1002/ajoc.202400076",

language = "英语",

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T1 - Hypervalent Iodine Mediated Synthesis of 2-Aminobenzazoles and 2-Aminobenzothiazoles

AU - Gu, Yi

AU - Li, Yao Dong

AU - Ge, Ye

AU - Huang, Jiang Long

AU - Xu, Hua Jin

AU - Hu, Yi

PY - 2024/6

Y1 - 2024/6

N2 - The hypervalent iodine mediated, silica gel promoted synthesis of 2-aminobenzazoles and 2-aminobenzothiazole derivatives under metal-free mild conditions within short time (30 min) has been developed. Under this process, PhI(COOCF3)2 (PIFA) or PhI(COOCH3)2 (PIDA) acts as an oxidant and radical initiator direct activated the ortho-C−H bond of substrate, silica gel as weakly lewis acid effectively increased the reactivity of the reaction system. This method is compatible with various of arylurea and arylthiourea substrates, which is green, efficient, simple to operate and suitable for practical application.

AB - The hypervalent iodine mediated, silica gel promoted synthesis of 2-aminobenzazoles and 2-aminobenzothiazole derivatives under metal-free mild conditions within short time (30 min) has been developed. Under this process, PhI(COOCF3)2 (PIFA) or PhI(COOCH3)2 (PIDA) acts as an oxidant and radical initiator direct activated the ortho-C−H bond of substrate, silica gel as weakly lewis acid effectively increased the reactivity of the reaction system. This method is compatible with various of arylurea and arylthiourea substrates, which is green, efficient, simple to operate and suitable for practical application.

KW - Arylurea

KW - cyclization

KW - metal-free

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DO - 10.1002/ajoc.202400076

M3 - 文章

AN - SCOPUS:85193268886

SN - 2193-5807

VL - 13

JO - Asian Journal of Organic Chemistry

JF - Asian Journal of Organic Chemistry

IS - 6

M1 - e202400076

ER -

Hypervalent Iodine Mediated Synthesis of 2-Aminobenzazoles and 2-Aminobenzothiazoles

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