Iron-Catalyzed Reductive Ring-Rearrangement Reaction of Bridged Benzo[b]oxocin-4-ones with Grignard Reagents to Afford Bridged Benzo[b]oxocin-2-ols

Yishuai Fan, Haoran Yang, Ri Peng, Dunru Zhu, Ruwei Shen

科研成果: 期刊稿件文章同行评审

摘要

An iron-catalyzed reductive ring-rearrangement reaction of bridged benzo[b]oxocin-4-ones with Grignard reagents to produce bridged benzo[b]oxocin-2-ols is reported. Mechanistic studies indicate that an iron redox catalysis cycle involving oxidative addition to the C-O bond by low-valence iron and β-methoxyl elimination as key steps operates in this reaction.

源语言英语
页(从-至)2693-2699
页数7
期刊Organic Letters
27
11
DOI
出版状态已出版 - 21 3月 2025

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