Nickel-catalyzed α-arylation of zinc enolates with polyfluoroarenes via C-F bond activation under neutral conditions

Daohong Yu; Chang Sheng Wang; Cheng Yao; Qilong Shen; Long Lu

doi:10.1021/ol502499q

Nickel-catalyzed α-arylation of zinc enolates with polyfluoroarenes via C-F bond activation under neutral conditions

Daohong Yu, Chang Sheng Wang, Cheng Yao, Qilong Shen, Long Lu

CAS - Shanghai Institute of Organic Chemistry

科研成果: 期刊稿件 › 文章 › 同行评审

40 引用（Scopus）

摘要

The first nickel-catalyzed α-arylation of 2-(polyfluorophenyl) pyridine with zinc enolates of esters or amides via C-F bond activation under neutral conditions is described. A variety of functional groups such as ester, amide, ether, and amine were tolerated. This method provides a simple and useful tool to synthesize fluorinated α-aryl carboxylic acids and α-aryl amides that are important intermediates for drug discovery.

源语言	英语
页（从-至）	5544-5547
页数	4
期刊	Organic Letters
卷	16
期	21
DOI	https://doi.org/10.1021/ol502499q
出版状态	已出版 - 7 11月 2014

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abstract = "The first nickel-catalyzed α-arylation of 2-(polyfluorophenyl) pyridine with zinc enolates of esters or amides via C-F bond activation under neutral conditions is described. A variety of functional groups such as ester, amide, ether, and amine were tolerated. This method provides a simple and useful tool to synthesize fluorinated α-aryl carboxylic acids and α-aryl amides that are important intermediates for drug discovery.",

author = "Daohong Yu and Wang, {Chang Sheng} and Cheng Yao and Qilong Shen and Long Lu",

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AU - Yu, Daohong

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AU - Shen, Qilong

AU - Lu, Long

PY - 2014/11/7

Y1 - 2014/11/7

N2 - The first nickel-catalyzed α-arylation of 2-(polyfluorophenyl) pyridine with zinc enolates of esters or amides via C-F bond activation under neutral conditions is described. A variety of functional groups such as ester, amide, ether, and amine were tolerated. This method provides a simple and useful tool to synthesize fluorinated α-aryl carboxylic acids and α-aryl amides that are important intermediates for drug discovery.

AB - The first nickel-catalyzed α-arylation of 2-(polyfluorophenyl) pyridine with zinc enolates of esters or amides via C-F bond activation under neutral conditions is described. A variety of functional groups such as ester, amide, ether, and amine were tolerated. This method provides a simple and useful tool to synthesize fluorinated α-aryl carboxylic acids and α-aryl amides that are important intermediates for drug discovery.

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Nickel-catalyzed α-arylation of zinc enolates with polyfluoroarenes via C-F bond activation under neutral conditions

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