Nickel-catalyzed cross-electrophile couplings of aryl fluorosulfates with vinyl chlorosilanes

An efficient cross-electrophile couplings of aryl fluorosulfates with vinyl chlorosilanes by using nickel as transition metal catalyst and manganese as reductant has been achieved. The reactions proceeded smoothly at room temperature via C-O bond activation to give a series of structurally varied aryl silanes in moderate to good yields, displaying broad substrate generality and good functional group compatibility. In addition, the reaction could be subjected to scale-up synthesis and be applied to late-stage functionalization of biologically active molecules.