One-pot total syntheses of natural products containing a THP-ring backbone: (±)-centrolobine and (±)-civet cat secretion

Hai Zhou; Teck Peng Loh

doi:10.1016/j.tetlet.2009.05.053

One-pot total syntheses of natural products containing a THP-ring backbone: (±)-centrolobine and (±)-civet cat secretion

Hai Zhou, Teck Peng Loh

Nanyang Technological University

科研成果: 期刊稿件 › 文章 › 同行评审

30 引用（Scopus）

摘要

A one-pot strategy is devised and applied to the total syntheses of natural products with a THP-ring backbone. A special feature of this one-pot synthesis is the recyclability of the indium complex byproduct generated from the indium-mediated allylation reaction for concurrent catalysis in subsequent steps. Centrolobine and civet cat secretion are synthesized via this new method in overall yields of 58% and 23%, respectively.

源语言	英语
页（从-至）	4368-4371
页数	4
期刊	Tetrahedron Letters
卷	50
期	30
DOI	https://doi.org/10.1016/j.tetlet.2009.05.053
出版状态	已出版 - 29 7月 2009
已对外发布	是

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10.1016/j.tetlet.2009.05.053

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AU - Loh, Teck Peng

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KW - Centrolobine

KW - Civet cat secretion

KW - Natural product

KW - One-pot

KW - THP

KW - Total synthesis

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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ER -

One-pot total syntheses of natural products containing a THP-ring backbone: (±)-centrolobine and (±)-civet cat secretion

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