Overcoming Electron-Withdrawing and Product-Inhibition Effects by Organocatalytic Aerobic Oxidation of Alkylpyridines and Related Alkylheteroarenes to Ketones

Hua Wang, Jie Liu, Jian Ping Qu, Yan Biao Kang

科研成果: 期刊稿件文章同行评审

32 引用 (Scopus)

摘要

An organocatalyzed aerobic benzylic C-H oxidation of alkyl and aryl heterocycles has been developed. This transition metal-free method is able to overcome the electron-withdrawing effect as well as product-inhibition effects in heterobenzylic radical oxidation. A variety of ketones bearing N-heterocyclic groups could be prepared under relatively mild conditions with moderate to high yields.

源语言英语
页(从-至)3942-3948
页数7
期刊Journal of Organic Chemistry
85
5
DOI
出版状态已出版 - 6 3月 2020

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