摘要
A green and practical electrochemical method for the synthesis of C-3-sulfonated benzothiophenes from 2-alkynylthioanisoles and sodium sulfinates was developed under oxidant- and catalyst-free conditions. Moderate to good yields of sulfonated benzothiophenes bearing important and useful functional groups have been achieved at a constant current. Preliminary mechanistic studies indicated a tandem radical addition-cyclization pathway. Moreover, the protocol is easy to scale up and exhibits good reaction efficiency.
源语言 | 英语 |
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页(从-至) | 2593-2601 |
页数 | 9 |
期刊 | Journal of Organic Chemistry |
卷 | 86 |
期 | 3 |
DOI | |
出版状态 | 已出版 - 5 2月 2021 |