Oxidant- And Catalyst-Free Synthesis of Sulfonated Benzothiophenes via Electrooxidative Tandem Cyclization

Dong Zhang, Jinlin Cai, Jinze Du, Xujia Wang, Wei He, Zhao Yang, Chengkou Liu, Zheng Fang, Kai Guo

科研成果: 期刊稿件文章同行评审

39 引用 (Scopus)

摘要

A green and practical electrochemical method for the synthesis of C-3-sulfonated benzothiophenes from 2-alkynylthioanisoles and sodium sulfinates was developed under oxidant- and catalyst-free conditions. Moderate to good yields of sulfonated benzothiophenes bearing important and useful functional groups have been achieved at a constant current. Preliminary mechanistic studies indicated a tandem radical addition-cyclization pathway. Moreover, the protocol is easy to scale up and exhibits good reaction efficiency.

源语言英语
页(从-至)2593-2601
页数9
期刊Journal of Organic Chemistry
86
3
DOI
出版状态已出版 - 5 2月 2021

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