Palladium-Catalyzed Regioselectivity C─H Oxidation of Aromatics Utilizing Removable Directing Group Strategy

Shuwei Zhu, Yong Wang, Fumeng Yin, Yuqing Gu, Hongjun Zhu

科研成果: 期刊稿件文章同行评审

1 引用 (Scopus)

摘要

An efficient pyridine-assisted o-acetoxylation of 2-phenoxypyridines has been developed using AcOH as solvent and acetoxy source through Pd(II)-catalyzed C─H bond activation. The protocol exhibits high regioselectivity and functional group tolerance with yields up to 89%. Moreover, the 2-pyridyloxyl and acetyl groups can be readily removed, which provides indirect access to obtain pyrocatechol. Control experiments indicate that the reaction involves free radical pathway and C─H activation may be the rate-determining step.

源语言英语
文章编号e202405019
期刊ChemistrySelect
10
1
DOI
出版状态已出版 - 8 1月 2025

指纹

探究 'Palladium-Catalyzed Regioselectivity C─H Oxidation of Aromatics Utilizing Removable Directing Group Strategy' 的科研主题。它们共同构成独一无二的指纹。

引用此