摘要
An efficient pyridine-assisted o-acetoxylation of 2-phenoxypyridines has been developed using AcOH as solvent and acetoxy source through Pd(II)-catalyzed C─H bond activation. The protocol exhibits high regioselectivity and functional group tolerance with yields up to 89%. Moreover, the 2-pyridyloxyl and acetyl groups can be readily removed, which provides indirect access to obtain pyrocatechol. Control experiments indicate that the reaction involves free radical pathway and C─H activation may be the rate-determining step.
源语言 | 英语 |
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文章编号 | e202405019 |
期刊 | ChemistrySelect |
卷 | 10 |
期 | 1 |
DOI | |
出版状态 | 已出版 - 8 1月 2025 |