TY - JOUR
T1 - Perfluoroalkyl Editing of Fluoroalkynes
T2 - Chemo-, Regio-, and Stereoselective Synthesis of (E)-(2-Amino-fluoroalkenyl)pyrimidines
AU - Li, Xiao Ying
AU - Tang, Ming Yao
AU - Tong, Qian
AU - Ge, Danhua
AU - Ma, Mengtao
AU - Shen, Zhi Liang
AU - Chu, Xue Qiang
N1 - Publisher Copyright:
© 2025 American Chemical Society.
PY - 2025/3/7
Y1 - 2025/3/7
N2 - A chemo-, regio-, and stereoselective condensation reaction of perfluoroalkyl alkynes (PFAAs), (CH2O)n, and (NH4)2CO3 through the cleavage of five inert C(sp3)-F bonds at three distinct carbon sites, thereby establishing an unprecedented platform for synthesizing structurally unique (E)-(2-amino-fluoroalkenyl)pyrimidines, is first developed. Remarkably, this reaction features mild reaction conditions, good compatibility with various functional groups, excellent E-stereoselectivity, late-stage modification of complex molecules, scalability, and versatile synthetic transformations of the resulting heterocyclic compounds.(Figure presented.)
AB - A chemo-, regio-, and stereoselective condensation reaction of perfluoroalkyl alkynes (PFAAs), (CH2O)n, and (NH4)2CO3 through the cleavage of five inert C(sp3)-F bonds at three distinct carbon sites, thereby establishing an unprecedented platform for synthesizing structurally unique (E)-(2-amino-fluoroalkenyl)pyrimidines, is first developed. Remarkably, this reaction features mild reaction conditions, good compatibility with various functional groups, excellent E-stereoselectivity, late-stage modification of complex molecules, scalability, and versatile synthetic transformations of the resulting heterocyclic compounds.(Figure presented.)
UR - http://www.scopus.com/inward/record.url?scp=86000433601&partnerID=8YFLogxK
U2 - 10.1021/acs.orglett.5c00381
DO - 10.1021/acs.orglett.5c00381
M3 - 文章
AN - SCOPUS:86000433601
SN - 1523-7060
VL - 27
SP - 2235
EP - 2240
JO - Organic Letters
JF - Organic Letters
IS - 9
ER -