Photocatalytic Redox-Neutral C(sp3)-C(sp3) Cleaving Transalkylation of Heteroarenes

Shu Hui Lei, Yu Fan Zou, Jian Ping Qu, Yan Biao Kang

科研成果: 期刊稿件文章同行评审

摘要

In this work, a photocatalytic redox-neutral carbon-carbon bond metathesis and transalkylation of heteroarenes was established. When CBZ6 was used as the photocatalyst, alkyl migration from 2-alkyl pyrrolidines or piperidines to heteroaryl nitriles occurred, affording heteroaryl-substituted tertiary alkyl ethers in up to 98% yields. The cyanyl groups released from nitrites are trapped by alkyl donors to form 2-cyano pyrrolidines or piperidines. These nitriles can be recycled for the regeneration of alkyl donors. A wide range of substrates has been proven to be suitable. Preliminary mechanistic investigations revealed the photocatalytic nature of this reaction.

源语言英语
期刊Journal of Organic Chemistry
DOI
出版状态已接受/待刊 - 2025

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