Preparation of acetylized polystyrene carrier by Friedel-Crafts acetylation reaction

The functional acetylized polystyrene particles were prepared by Friedel-Crafts acetylation on polystyrene (PS). The obtained particles may be used as the solid support in flexible immobilization of enzyme, and ion exchange and adsorption. The reported method avoided the toxic problem caused by classic chloromethylation process and eliminated side reactions such as multi-substitution and secondary cross link. In this work, the effects of catalyst, acylating reagent, time and solvent were studied to achieve optimum results. By controlling the amount of materials (catalyst, acylating reagent), the quantitative loading of acetylized resin could be attained. The maximum loading of the acetyl polystyrene could be to 5.9 mmol/g.