TY - JOUR
T1 - Preparation of High Purity Lactide Using a High-Boiling-Point Alcohol Immobilization Method
AU - Wang, Guocai
AU - Tang, Shigui
AU - Cao, Fei
AU - Wu, Hongli
AU - Jia, Honghua
AU - Wei, Ping
AU - Ouyang, Pingkai
N1 - Publisher Copyright:
© 2018 American Chemical Society.
PY - 2018/6/6
Y1 - 2018/6/6
N2 - During the lactide producing process, volatile impurities, such as lactic acid and its dimer, are simultaneously distilled out with lactide. To remove these impurities, many post-treatments were needed. Herein, we present a novel approach to obtain high purity lactide by adding high-boiling-point alcohols to immobilize these volatile impurities. A series of high-boiling-point alcohols were screened and pentaerythritol was found to be the best immobilization reagent. When the molar ratio of lactic acid's carboxylic group and pentaerythritol's hydroxyl group was 15:1, lactide with 99% GC purity was directly distilled out and no traces of lactic acid and its dimer were detected. The results of HPLC-MS revealed that the distillation residues were esters of pentaerythritol with lactic acid or its oligomer. This indicated that volatile impurities were immobilized in distillation residues. The distillation residues were reused for 4 runs, and the purities of lactide were all over 98%.
AB - During the lactide producing process, volatile impurities, such as lactic acid and its dimer, are simultaneously distilled out with lactide. To remove these impurities, many post-treatments were needed. Herein, we present a novel approach to obtain high purity lactide by adding high-boiling-point alcohols to immobilize these volatile impurities. A series of high-boiling-point alcohols were screened and pentaerythritol was found to be the best immobilization reagent. When the molar ratio of lactic acid's carboxylic group and pentaerythritol's hydroxyl group was 15:1, lactide with 99% GC purity was directly distilled out and no traces of lactic acid and its dimer were detected. The results of HPLC-MS revealed that the distillation residues were esters of pentaerythritol with lactic acid or its oligomer. This indicated that volatile impurities were immobilized in distillation residues. The distillation residues were reused for 4 runs, and the purities of lactide were all over 98%.
UR - http://www.scopus.com/inward/record.url?scp=85047433859&partnerID=8YFLogxK
U2 - 10.1021/acs.iecr.8b01088
DO - 10.1021/acs.iecr.8b01088
M3 - 文章
AN - SCOPUS:85047433859
SN - 0888-5885
VL - 57
SP - 7711
EP - 7716
JO - Industrial and Engineering Chemistry Research
JF - Industrial and Engineering Chemistry Research
IS - 22
ER -