Preparation of paclitaxel-loaded microspheres with Fe ₃O ₄nanoparticles and study of their target-orientation and sustained-release property

Paclitaxel-loaded microspheres with magnetic Fe ₃O ₄ nanoparticles were synthesized with albumin as carrier. The morphology was characterized by high-resolution transmission electron microscopy (HRTEM). The drug-loading rate and entrapment rate of the microspheres were researched by ultraviolet and visible spectrophotometer. The inhibition action of taxol microspheres to growth of esophagus cancer Eca109 cell were examined by MTT method. The result shows that it is regular spherical. The mean size and size distribution of microspheres are 275.6nm and 144.3nm by Zetasizer3000. The drug-loading rate is 3.013% and the entrapment rate is 35.26%. It has excellent target-orientation and sustained-release property which can prevent the growth of Eca109 cell.