Preparation of paclitaxel-loaded microspheres with magnetic nanoparticles

Sheng Cui; Xiaodong Shen; Ruihua Shi; Benlan Lin; Ping Chen

doi:10.1007/s11706-007-0070-5

Preparation of paclitaxel-loaded microspheres with magnetic nanoparticles

Sheng Cui, Xiaodong Shen, Ruihua Shi, Benlan Lin, Ping Chen

材料科学与工程学院

科研成果: 期刊稿件 › 文章 › 同行评审

1 引用（Scopus）

摘要

The objective of this paper was to prepare paclitaxel-loaded microspheres, a kind of target-orientation anticancer drug. The paclitaxel-loaded microspheres were prepared with magnetic Fe₃O₄ nanoparticles and taxol. The morphology was characterized by scanning electron microscopy (SEM), and the average size and the size distribution were determined by a laser-size distributing instrument. High performance liquid chromatography (HPLC) was used to measure the paxlitaxel content. Experimental results indicated that the effective drug loading and the entrapment ratio of paclitaxel-loaded microspheres were 1.83% and 92.62%, respectively.

源语言	英语
页（从-至）	383-387
页数	5
期刊	Frontiers of Materials Science in China
卷	1
期	4
DOI	https://doi.org/10.1007/s11706-007-0070-5
出版状态	已出版 - 10月 2007

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title = "Preparation of paclitaxel-loaded microspheres with magnetic nanoparticles",

abstract = "The objective of this paper was to prepare paclitaxel-loaded microspheres, a kind of target-orientation anticancer drug. The paclitaxel-loaded microspheres were prepared with magnetic Fe3O4 nanoparticles and taxol. The morphology was characterized by scanning electron microscopy (SEM), and the average size and the size distribution were determined by a laser-size distributing instrument. High performance liquid chromatography (HPLC) was used to measure the paxlitaxel content. Experimental results indicated that the effective drug loading and the entrapment ratio of paclitaxel-loaded microspheres were 1.83% and 92.62%, respectively.",

keywords = "Electron microscopy, Magnetic materials, Oxides",

author = "Sheng Cui and Xiaodong Shen and Ruihua Shi and Benlan Lin and Ping Chen",

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AU - Cui, Sheng

AU - Shen, Xiaodong

AU - Shi, Ruihua

AU - Lin, Benlan

AU - Chen, Ping

PY - 2007/10

Y1 - 2007/10

N2 - The objective of this paper was to prepare paclitaxel-loaded microspheres, a kind of target-orientation anticancer drug. The paclitaxel-loaded microspheres were prepared with magnetic Fe3O4 nanoparticles and taxol. The morphology was characterized by scanning electron microscopy (SEM), and the average size and the size distribution were determined by a laser-size distributing instrument. High performance liquid chromatography (HPLC) was used to measure the paxlitaxel content. Experimental results indicated that the effective drug loading and the entrapment ratio of paclitaxel-loaded microspheres were 1.83% and 92.62%, respectively.

AB - The objective of this paper was to prepare paclitaxel-loaded microspheres, a kind of target-orientation anticancer drug. The paclitaxel-loaded microspheres were prepared with magnetic Fe3O4 nanoparticles and taxol. The morphology was characterized by scanning electron microscopy (SEM), and the average size and the size distribution were determined by a laser-size distributing instrument. High performance liquid chromatography (HPLC) was used to measure the paxlitaxel content. Experimental results indicated that the effective drug loading and the entrapment ratio of paclitaxel-loaded microspheres were 1.83% and 92.62%, respectively.

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KW - Magnetic materials

KW - Oxides

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JO - Frontiers of Materials Science in China

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Preparation of paclitaxel-loaded microspheres with magnetic nanoparticles

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