TY - JOUR
T1 - Progress in microbial production of succinic acid
AU - Liu, Rongming
AU - Liang, Liya
AU - Wu, Mingke
AU - Jiang, Min
PY - 2013
Y1 - 2013
N2 - Succinic acid is one of the key intermediates in the tricarboxylic acid cycle (TCA) and has huge potentials in biopolymer, food, medicine applications. This article reviews recent research progress in the production of succinic acid by microbial fermentation, including discovery and screening of the succinic-acid-producing microbes, the progress of genetic engineering strategy and metabolic engineering technology for construction of succinic acid-producing strains, and fermentation process control and optimization. Finally, we discussed the limitation of current progress and proposed the future research needs for microbial production of succinic acid.
AB - Succinic acid is one of the key intermediates in the tricarboxylic acid cycle (TCA) and has huge potentials in biopolymer, food, medicine applications. This article reviews recent research progress in the production of succinic acid by microbial fermentation, including discovery and screening of the succinic-acid-producing microbes, the progress of genetic engineering strategy and metabolic engineering technology for construction of succinic acid-producing strains, and fermentation process control and optimization. Finally, we discussed the limitation of current progress and proposed the future research needs for microbial production of succinic acid.
KW - Genetic engineering
KW - Metabolic engineering
KW - Process control and optimization
KW - Succinic acid, strain breeding
UR - http://www.scopus.com/inward/record.url?scp=84890811434&partnerID=8YFLogxK
M3 - 文章
C2 - 24432654
AN - SCOPUS:84890811434
SN - 1000-3061
VL - 29
SP - 1386
EP - 1397
JO - Shengwu Gongcheng Xuebao/Chinese Journal of Biotechnology
JF - Shengwu Gongcheng Xuebao/Chinese Journal of Biotechnology
IS - 10
ER -