TY - JOUR
T1 - Recent Advances in Tumor Microenvironment Hydrogen Peroxide-Responsive Materials for Cancer Photodynamic Therapy
AU - Yang, Nan
AU - Xiao, Wanyue
AU - Song, Xuejiao
AU - Wang, Wenjun
AU - Dong, Xiaochen
N1 - Publisher Copyright:
© 2020, © 2020, The Author(s).
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Photodynamic therapy (PDT), as one of the noninvasive clinical cancer phototherapies, suffers from the key drawback associated with hypoxia at the tumor microenvironment (TME), which plays an important role in protecting tumor cells from damage caused by common treatments. High concentration of hydrogen peroxide (H2O2), one of the hallmarks of TME, has been recognized as a double-edged sword, posing both challenges, and opportunities for cancer therapy. The promising perspectives, strategies, and approaches for enhanced tumor therapies, including PDT, have been developed based on the fast advances in H2O2-enabled theranostic nanomedicine. In this review, we outline the latest advances in H2O2-responsive materials, including organic and inorganic materials for enhanced PDT. Finally, the challenges and opportunities for further research on H2O2-responsive anticancer agents are envisioned[Figure not available: see fulltext.].
AB - Photodynamic therapy (PDT), as one of the noninvasive clinical cancer phototherapies, suffers from the key drawback associated with hypoxia at the tumor microenvironment (TME), which plays an important role in protecting tumor cells from damage caused by common treatments. High concentration of hydrogen peroxide (H2O2), one of the hallmarks of TME, has been recognized as a double-edged sword, posing both challenges, and opportunities for cancer therapy. The promising perspectives, strategies, and approaches for enhanced tumor therapies, including PDT, have been developed based on the fast advances in H2O2-enabled theranostic nanomedicine. In this review, we outline the latest advances in H2O2-responsive materials, including organic and inorganic materials for enhanced PDT. Finally, the challenges and opportunities for further research on H2O2-responsive anticancer agents are envisioned[Figure not available: see fulltext.].
KW - Cancer
KW - HO-responsive
KW - Nanomaterials
KW - Photodynamic therapy
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85077268795&partnerID=8YFLogxK
U2 - 10.1007/s40820-019-0347-0
DO - 10.1007/s40820-019-0347-0
M3 - 文献综述
AN - SCOPUS:85077268795
SN - 2311-6706
VL - 12
JO - Nano-Micro Letters
JF - Nano-Micro Letters
IS - 1
M1 - 15
ER -
