Regioselective synthesis of highly functionalized 3-spiropyrrolidine/ pyrrolizidine oxindoles and acenaphthenones via one-pot four-component [3+2] cycloaddition

A facile and efficient entry into highly functionalized 3-spiropyrrolidine oxindoles and 3-spiropyrrolizidine oxindoles, as well as to 3-spiropyrrolidine acenaphthenones via one-pot four-component reactions of 3-cyanoacetylindoles, aldehydes, isatin/acenaphthylene-1,2-dione and amino acid has been developed. Particularly valuable features of this method include high yields of products, broad substrate scope and a straightforward procedure.