Rolling Stone Gathers Moss: Rolling Microneedles Generate Meta Microfluidic Microneedles (MMM)

Qian Zhou, Kaiyi Dong, Meng Wei, Bingfang He, Bingbing Gao

科研成果: 期刊稿件文章同行评审

31 引用 (Scopus)

摘要

Microfluidic chips play crucial roles while lack satisfactory controllability and comprehensive functionality. Inspired by biological systems, this study proposes a method utilizing rolling microneedles (RMNs) to generate muti-structured templates, realizing photonic crystal membrane (PC) based meta microfluidic microneedle chip (MMM) for efficient wound management. This approach offers advantages in terms of speed and cost-effectiveness, achieving dual-sided permeation and patterned design by directly RMNs at desired locations, serving as both template tools for microneedle fabrication. The integration of RMNs with a PC membrane results in the design of 3D multilayer microfluidic channels, effectively addressing issues related to spontaneous fluid flow. As fluid reaches the PC membrane, it generates distinctive structural colors and exhibits fluorescence enhancement, enabling the monitoring of inflammatory factors in mouse wounds and facilitating efficient wound management. In summary, this preparation method involving RMNs paves the way for the design and fluid control of microfluidic chips. This bioinspired patch holds significant potential not only for wound management but also for areas such as clinical drug delivery and point-of-care testing (POCT).

源语言英语
文章编号2316565
期刊Advanced Functional Materials
34
25
DOI
出版状态已出版 - 19 6月 2024

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