TY - JOUR
T1 - Single nanoparticles as versatile phototheranostics for tri-modal imaging-guided photothermal therapy
AU - Lu, Xiaomei
AU - Chen, Jiaqi
AU - Li, Jie
AU - Xia, Bing
AU - Xu, Jingzeng
AU - Wang, Qi
AU - Xie, Chen
AU - Fan, Quli
AU - Huang, Wei
N1 - Publisher Copyright:
© 2019 The Royal Society of Chemistry.
PY - 2019/9
Y1 - 2019/9
N2 - Development of versatile phototheranostics is highly desirable for cancer theranostics. Herein, a novel organic conjugated polymer (named DPP-TT) with excellent optical properties was designed and prepared. Based on single-component DPP-TT, single DPP-TT NPs as versatile phototheranostics were developed by a simple nanoprecipitation method. The obtained NPs exhibited good water solubility, excellent biocompatibility, outstanding photostability, strong NIR-I light absorption, and appropriate NIR-II fluorescence emission. Importantly, such NPs presented high photothermal conversion efficiency. From the investigations performed in vitro and in vivo, it was observed that DPP-TT NPs show remarkable performance for cancer theranostics, benefiting from single 808 nm laser-induced tri-modal (NIR-II fluorescence/photoacoustic/thermal) imaging-guided photothermal therapy.
AB - Development of versatile phototheranostics is highly desirable for cancer theranostics. Herein, a novel organic conjugated polymer (named DPP-TT) with excellent optical properties was designed and prepared. Based on single-component DPP-TT, single DPP-TT NPs as versatile phototheranostics were developed by a simple nanoprecipitation method. The obtained NPs exhibited good water solubility, excellent biocompatibility, outstanding photostability, strong NIR-I light absorption, and appropriate NIR-II fluorescence emission. Importantly, such NPs presented high photothermal conversion efficiency. From the investigations performed in vitro and in vivo, it was observed that DPP-TT NPs show remarkable performance for cancer theranostics, benefiting from single 808 nm laser-induced tri-modal (NIR-II fluorescence/photoacoustic/thermal) imaging-guided photothermal therapy.
UR - http://www.scopus.com/inward/record.url?scp=85071361217&partnerID=8YFLogxK
U2 - 10.1039/c9bm00997c
DO - 10.1039/c9bm00997c
M3 - 文章
C2 - 31361290
AN - SCOPUS:85071361217
SN - 2047-4830
VL - 7
SP - 3609
EP - 3613
JO - Biomaterials Science
JF - Biomaterials Science
IS - 9
ER -
