摘要
An efficient nickel-catalyzed, iron-mediated hydrofluoroalkylation of alkynes with bromodifluoroacetate or perfluoroalkyl iodide was developed. The reactions proceeded efficiently via a radical reaction pathway to give fluoroalkylated (Z)-alkenes in moderate to good yields with good control of stereoselectivity (up to 99 : 1 Z/E), exhibiting both wide substrate scope and broad functional group tolerance. In addition, the method also entailed the easy functionalization of alkyne-tethered complex molecules derived from sugars and pharmaceuticals.
源语言 | 英语 |
---|---|
页(从-至) | 6377-6383 |
页数 | 7 |
期刊 | Organic Chemistry Frontiers |
卷 | 8 |
期 | 22 |
DOI | |
出版状态 | 已出版 - 21 11月 2021 |