Stereoselective synthesis of fluoroalkylated (: Z)-alkene via nickel-catalyzed and iron-mediated hydrofluoroalkylation of alkynes

Xiang Rui Li, Wen Xin Li, Zhuo Wen Zhang, Chuanji Shen, Xiaocong Zhou, Xue Qiang Chu, Weidong Rao, Zhi Liang Shen

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16 引用 (Scopus)

摘要

An efficient nickel-catalyzed, iron-mediated hydrofluoroalkylation of alkynes with bromodifluoroacetate or perfluoroalkyl iodide was developed. The reactions proceeded efficiently via a radical reaction pathway to give fluoroalkylated (Z)-alkenes in moderate to good yields with good control of stereoselectivity (up to 99 : 1 Z/E), exhibiting both wide substrate scope and broad functional group tolerance. In addition, the method also entailed the easy functionalization of alkyne-tethered complex molecules derived from sugars and pharmaceuticals.

源语言英语
页(从-至)6377-6383
页数7
期刊Organic Chemistry Frontiers
8
22
DOI
出版状态已出版 - 21 11月 2021

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