Studies on copper(I)-catalyzed highly regio- and stereo-selective hydroboration of alkynamides

Guangke He; Shan Chen; Qiang Wang; Hai Huang; Qijun Zhang; Dongming Zhang; Rong Zhang; Hongjun Zhu

doi:10.1039/c4ob00979g

Studies on copper(I)-catalyzed highly regio- and stereo-selective hydroboration of alkynamides

Guangke He, Shan Chen, Qiang Wang, Hai Huang, Qijun Zhang, Dongming Zhang, Rong Zhang, Hongjun Zhu

化学与分子工程学院

Nanjing Tech University

科研成果: 期刊稿件 › 文章 › 同行评审

40 引用（Scopus）

摘要

The copper(i)-catalyzed hydroboration of alkynamides with B ₂pin₂ afforded the alkenamide boronates in 66% to nearly quantitative yields with high regio- and stereo-selectivity. It was interesting to note that the regio-selectivity of the reaction is opposite to that observed in the carbometallation reaction of alkynamides, and the resulting alkenyl boronates provided access to α,-disubstituted (Z)-alkenamides through further elaboration. This journal is

源语言	英语
页（从-至）	5945-5953
页数	9
期刊	Organic and Biomolecular Chemistry
卷	12
期	31
DOI	https://doi.org/10.1039/c4ob00979g
出版状态	已出版 - 21 8月 2014

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AU - He, Guangke

AU - Chen, Shan

AU - Wang, Qiang

AU - Huang, Hai

AU - Zhang, Qijun

AU - Zhang, Dongming

AU - Zhang, Rong

AU - Zhu, Hongjun

PY - 2014/8/21

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AB - The copper(i)-catalyzed hydroboration of alkynamides with B 2pin2 afforded the alkenamide boronates in 66% to nearly quantitative yields with high regio- and stereo-selectivity. It was interesting to note that the regio-selectivity of the reaction is opposite to that observed in the carbometallation reaction of alkynamides, and the resulting alkenyl boronates provided access to α,-disubstituted (Z)-alkenamides through further elaboration. This journal is

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JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

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ER -

Studies on copper(I)-catalyzed highly regio- and stereo-selective hydroboration of alkynamides

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