TY - JOUR
T1 - Study on synthesis of trandolapril
AU - Fang, Zheng
AU - Yang, Zhao
AU - Wei, Ping
AU - Chen, Guo Guang
PY - 2008/4
Y1 - 2008/4
N2 - OBJECTIVE: To study the synthesis of trandolapril. METHODS: Trandolapril was synthesized from 1,1,3,3-tetra-methoxypropane by fractional hydrolysation, condensation, dehydration, Diels-Alder reaction, high pressure hydrogenation, cyclizatiohydrolysation, esterification, chiral resolution on silica gel column and hydrogenation with catalyst. RESULTS: Structures of key intermediates were confirmed by MS and 1H-NMR data. The structure of trandolapril was identified by MS, IR, NMR and elemental analysis. CONCLUSION: Each step in this route was easily operated and the yield was higher than that reported. This method was successful without using expensive reagents and had the potential for industry.
AB - OBJECTIVE: To study the synthesis of trandolapril. METHODS: Trandolapril was synthesized from 1,1,3,3-tetra-methoxypropane by fractional hydrolysation, condensation, dehydration, Diels-Alder reaction, high pressure hydrogenation, cyclizatiohydrolysation, esterification, chiral resolution on silica gel column and hydrogenation with catalyst. RESULTS: Structures of key intermediates were confirmed by MS and 1H-NMR data. The structure of trandolapril was identified by MS, IR, NMR and elemental analysis. CONCLUSION: Each step in this route was easily operated and the yield was higher than that reported. This method was successful without using expensive reagents and had the potential for industry.
KW - Chiral resolution
KW - Synthesis
KW - Trandolapril
UR - http://www.scopus.com/inward/record.url?scp=53049106953&partnerID=8YFLogxK
M3 - 文章
AN - SCOPUS:53049106953
SN - 1001-2494
VL - 43
SP - 632
EP - 635
JO - Chinese Pharmaceutical Journal
JF - Chinese Pharmaceutical Journal
IS - 8
ER -