Synthesis and IR/MS study of 3,5-dimethyladamantanamine hydrochloride salt

This paper studied the synthesis of memantine hydrochloride characteristics by optimizing the synthetic route in the bromination of acid hydrolysis under the conditions of acetonitrile and the final salt formation reaction, so that memantine hydrochloride in an overall yield of the products from the 67.3 % reported in the literature increased to 81.5 %. Compared to 1,3-dimethyl adamantane and 3,5-dimethyladamantanamine, the infrared spectra showed the characteristic absorptions of 3,5-dimethyl-adamantanamine hydrochloride. Especially by the use of ESI method Spray ionization mass spectrometry analysis of fragments of memantine hydrochloride mass characteristics of ammonia compounds. By IR and MS studies to determine the spectrum of memantine hydrochloride microscopic molecular structure of ammonia.