Synthesis of Heterocyclic Analogues of Tamoxifen as Potential Antiestrogens

Natarajan Srikanth; Choon Hong Tan; Siu Choon Ng; Teck Peng Loh; Lip Lin Koh; Keng Yeow Sim

doi:10.1039/a701410d

Synthesis of Heterocyclic Analogues of Tamoxifen as Potential Antiestrogens

Natarajan Srikanth, Choon Hong Tan, Siu Choon Ng, Teck Peng Loh, Lip Lin Koh, Keng Yeow Sim

National University of Singapore

科研成果: 期刊稿件 › 文章 › 同行评审

4 引用（Scopus）

摘要

The synthesis of (E/Z)-1-aryl-2-phenyl-1-(2-thienyI/selenophen-2-yl)but-1-enes, derived from 2- phenyl-1-(2-thienyl/ selenophen-2-y1)butan-1-ones, is described; the key steps in the synthesis involve the reaction of the butan-1-ones with 4-(2-morpholinoethoxy)phenyl bromide, followed by dehydration of the resulting carbinols to give the target compounds which are separated by fractional recrystallisation.

源语言	英语
页（从-至）	274-275
页数	2
期刊	Journal of Chemical Research - Part S
期	8
DOI	https://doi.org/10.1039/a701410d
出版状态	已出版 - 1997
已对外发布	是

访问文件

10.1039/a701410d

其它文件与链接

链接到 Scopus 的出版物

引用此

@article{dcabd39fcb994ad594c39d28c78ef371,

title = "Synthesis of Heterocyclic Analogues of Tamoxifen as Potential Antiestrogens",

abstract = "The synthesis of (E/Z)-1-aryl-2-phenyl-1-(2-thienyI/selenophen-2-yl)but-1-enes, derived from 2- phenyl-1-(2-thienyl/ selenophen-2-y1)butan-1-ones, is described; the key steps in the synthesis involve the reaction of the butan-1-ones with 4-(2-morpholinoethoxy)phenyl bromide, followed by dehydration of the resulting carbinols to give the target compounds which are separated by fractional recrystallisation.",

author = "Natarajan Srikanth and Tan, {Choon Hong} and Ng, {Siu Choon} and Loh, {Teck Peng} and Koh, {Lip Lin} and Sim, {Keng Yeow}",

year = "1997",

doi = "10.1039/a701410d",

language = "英语",

pages = "274--275",

journal = "Journal of Chemical Research - Part S",

issn = "0308-2342",

publisher = "Science Reviews Ltd",

number = "8",

}

TY - JOUR

T1 - Synthesis of Heterocyclic Analogues of Tamoxifen as Potential Antiestrogens

AU - Srikanth, Natarajan

AU - Tan, Choon Hong

AU - Ng, Siu Choon

AU - Loh, Teck Peng

AU - Koh, Lip Lin

AU - Sim, Keng Yeow

PY - 1997

Y1 - 1997

N2 - The synthesis of (E/Z)-1-aryl-2-phenyl-1-(2-thienyI/selenophen-2-yl)but-1-enes, derived from 2- phenyl-1-(2-thienyl/ selenophen-2-y1)butan-1-ones, is described; the key steps in the synthesis involve the reaction of the butan-1-ones with 4-(2-morpholinoethoxy)phenyl bromide, followed by dehydration of the resulting carbinols to give the target compounds which are separated by fractional recrystallisation.

AB - The synthesis of (E/Z)-1-aryl-2-phenyl-1-(2-thienyI/selenophen-2-yl)but-1-enes, derived from 2- phenyl-1-(2-thienyl/ selenophen-2-y1)butan-1-ones, is described; the key steps in the synthesis involve the reaction of the butan-1-ones with 4-(2-morpholinoethoxy)phenyl bromide, followed by dehydration of the resulting carbinols to give the target compounds which are separated by fractional recrystallisation.

UR - http://www.scopus.com/inward/record.url?scp=0001553521&partnerID=8YFLogxK

U2 - 10.1039/a701410d

DO - 10.1039/a701410d

M3 - 文章

AN - SCOPUS:0001553521

SN - 0308-2342

SP - 274

EP - 275

JO - Journal of Chemical Research - Part S

JF - Journal of Chemical Research - Part S

IS - 8

ER -

Synthesis of Heterocyclic Analogues of Tamoxifen as Potential Antiestrogens

摘要

访问文件

其它文件与链接

指纹

引用此