Synthetic studies towards anti-SARS agents: Application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate

Shu Sin Chng, Truong Giang Hoang, Wei Woon Wayne Lee, Mun Pun Tham, Hui Yvonne Ling, Teck Peng Loh

科研成果: 期刊稿件文章同行评审

13 引用 (Scopus)

摘要

AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV M pro). Synthesis of intermediate 1 and analogues proceeded via a highly diastereoselective indium-mediated allylation of α-aminoaldehydes.

源语言英语
页(从-至)9501-9504
页数4
期刊Tetrahedron Letters
45
52
DOI
出版状态已出版 - 20 12月 2004
已对外发布

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