Systematic study of phenyl substitutions in a terpyridine Zn2+ complex for pyrophosphate sensing in water

Zhongzheng Yu, Fang Wang, Sheng Lu, Xiaoqiang Chen

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摘要

Terpyridine Zn2+ complex-based pyrophosphate (PPi) fluorescent probes have shown promise, however, a systematic study on the optimal structure of terpyridine for PPi sensing is still lacking. In this study a series of six-coordinated terpyridine Zn2+ complexes were designed and synthesized. The impact of the position and the number of electron-donating groups on the aromatic ring of terpyridine, as well as changes in hydrophobicity, on the ability to selectively recognize PPi was explored. Six terpyridine Zn2+ complexes with meta-methoxy groups on the phenyl ring can detect PPi in aqueous solution through an AIE-mediated mechanism, exhibiting excellent selectivity for PPi over other nucleoside triphosphates (NTPs). More importantly, the introduction of an additional propoxy group at the para-position enhances the anti-interference capability and fluorescence response speed of the terpyridine Zn2+ complex towards PPi. Furthermore, four selected probes have also demonstrated the capability to monitor inorganic pyrophosphatase (IPP)-mediated PPi hydrolysis.

源语言英语
文章编号112874
期刊Dyes and Pigments
241
DOI
出版状态已出版 - 10月 2025

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