The first In(OTf)3-catalyzed conversion of kinetically formed homoallylic alcohols into the thermodynamically preferred regioisomers: Application to the synthesis of 22α-sterols

Teck Peng Loh, Kui Thong Tan, Qi Ying Hu

科研成果: 期刊稿件文章同行评审

61 引用 (Scopus)

摘要

A retro-ene reaction that generates the parent aldehyde and a sigmatropic rearrangement are involved in the In(OTf)3-catalyzed conversion of homoallylic alcohols 1 into the thermodynamically favored regioisomers 2. This method can be used for the stereocontrolled synthesis of linear homoallylic 22α-sterols from their readily accessible branched 22β isomers.

源语言英语
页(从-至)2921-2922
页数2
期刊Angewandte Chemie - International Edition
40
15
DOI
出版状态已出版 - 3 8月 2001
已对外发布

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