The synthesis of UDP-selective fluorescent probe and its imaging application in living cells

Haiyan Chen; Srinivasulu Kambam; Xintong Ren; Cheng Zheng; Fang Wang; Yong Wang; Jun Yin; Jingjing Xie; Xiaoqiang Chen

doi:10.1016/j.bmcl.2014.11.057

The synthesis of UDP-selective fluorescent probe and its imaging application in living cells

Haiyan Chen, Srinivasulu Kambam, Xintong Ren, Cheng Zheng, Fang Wang, Yong Wang, Jun Yin, Jingjing Xie, Xiaoqiang Chen

科研成果: 期刊稿件 › 文章 › 同行评审

8 引用（Scopus）

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A perylene-based probe was developed for uridine diphosphate (UDP) sensing and cell imaging. The probe presented about 4-fold fluorescence enhancement in the presence or absence of 100 equiv UDP. The selectivity toward UDP over other phosphor-containing anions was observed. The selective UDP sensing was speculated to be related to the binding affinities of Zn²⁺ ions in sensor with the uridine and phosphate moieties of UDP. Furthermore, this probe was also applied to image of UDP in living cells.

源语言	英语
页（从-至）	262-265
页数	4
期刊	Bioorganic and Medicinal Chemistry Letters
卷	25
期	2
DOI	https://doi.org/10.1016/j.bmcl.2014.11.057
出版状态	已出版 - 15 1月 2015

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abstract = "A perylene-based probe was developed for uridine diphosphate (UDP) sensing and cell imaging. The probe presented about 4-fold fluorescence enhancement in the presence or absence of 100 equiv UDP. The selectivity toward UDP over other phosphor-containing anions was observed. The selective UDP sensing was speculated to be related to the binding affinities of Zn2+ ions in sensor with the uridine and phosphate moieties of UDP. Furthermore, this probe was also applied to image of UDP in living cells.",

keywords = "Cell imaging, Fluorescent probe, Perylene, UDP",

author = "Haiyan Chen and Srinivasulu Kambam and Xintong Ren and Cheng Zheng and Fang Wang and Yong Wang and Jun Yin and Jingjing Xie and Xiaoqiang Chen",

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T1 - The synthesis of UDP-selective fluorescent probe and its imaging application in living cells

AU - Chen, Haiyan

AU - Kambam, Srinivasulu

AU - Ren, Xintong

AU - Zheng, Cheng

AU - Wang, Fang

AU - Wang, Yong

AU - Yin, Jun

AU - Xie, Jingjing

AU - Chen, Xiaoqiang

PY - 2015/1/15

Y1 - 2015/1/15

N2 - A perylene-based probe was developed for uridine diphosphate (UDP) sensing and cell imaging. The probe presented about 4-fold fluorescence enhancement in the presence or absence of 100 equiv UDP. The selectivity toward UDP over other phosphor-containing anions was observed. The selective UDP sensing was speculated to be related to the binding affinities of Zn2+ ions in sensor with the uridine and phosphate moieties of UDP. Furthermore, this probe was also applied to image of UDP in living cells.

AB - A perylene-based probe was developed for uridine diphosphate (UDP) sensing and cell imaging. The probe presented about 4-fold fluorescence enhancement in the presence or absence of 100 equiv UDP. The selectivity toward UDP over other phosphor-containing anions was observed. The selective UDP sensing was speculated to be related to the binding affinities of Zn2+ ions in sensor with the uridine and phosphate moieties of UDP. Furthermore, this probe was also applied to image of UDP in living cells.

KW - Cell imaging

KW - Fluorescent probe

KW - Perylene

KW - UDP

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U2 - 10.1016/j.bmcl.2014.11.057

DO - 10.1016/j.bmcl.2014.11.057

M3 - 文章

C2 - 25499877

AN - SCOPUS:84922331892

SN - 0960-894X

VL - 25

SP - 262

EP - 265

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

The synthesis of UDP-selective fluorescent probe and its imaging application in living cells

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