Tritylium Cation as Low Loading Lewis Acidic Organocatalyst in Povarov Reactions

Yu Huang, Chuanhong Qiu, Zhenjiang Li, Weiyang Feng, Haifeng Gan, Jingjing Liu, Kai Guo

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39 引用 (Scopus)

摘要

Triphenylmethylium cation catalyzed Povarov reactions with excellent yields in 1 h with a remarkably low loading (0.5 mol %) are disclosed. A Lewis acidic carbenium catalysis mechanism was proposed and validated. A three-component Povarov reaction in a batch was transferred into a two-stage microflow process, which resulted in a 60-fold reduction in reaction time from 2 h to 2 min with 89% separated yield.

源语言英语
页(从-至)47-52
页数6
期刊ACS Sustainable Chemistry and Engineering
4
1
DOI
出版状态已出版 - 4 1月 2016

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