Uniform and size-tunable dasatinib nanoemulsions synthesized by a high-throughput microreactor for enhanced temperature stability

Su Wang, Chao Li, Jiaxiang Zhang, Kaixuan Ma, Wanyao Zhang, Yan Gao, Xue Li, Jingsheng Zhang, Liang Guo, Yingying Nie, Yuguang Li, Ruiyan Sun, Ning Zhu, Wei He, Shuangfei Zhao, Kai Guo

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1 引用 (Scopus)

摘要

This study introduces a high-throughput microreactor for preparing dasatinib nanoemulsions with precise control over particle size and uniformity. Leveraging the microreactor's advantages in mass transfer and mixing, we established an empirical correlation to predict and adjust nanoemulsion properties. Optimized operational parameters enabled the synthesis of stable dasatinib nanoemulsions with narrow size distributions and mean diameters below 20 nm, maintaining their stability and transparency under various storage conditions.

源语言英语
页(从-至)3524-3527
页数4
期刊Chemical Communications
61
17
DOI
出版状态已出版 - 1 2月 2025

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