Visible-Light-Induced Trifluoromethylation of Allylic Alcohols

Bowen Li; Wubing Zeng; Lin Wang; Zhishuai Geng; Teck Peng Loh; Peizhong Xie

doi:10.1021/acs.orglett.1c01767

Visible-Light-Induced Trifluoromethylation of Allylic Alcohols

Bowen Li, Wubing Zeng, Lin Wang, Zhishuai Geng, Teck Peng Loh, Peizhong Xie

科研成果: 期刊稿件 › 文章 › 同行评审

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摘要

An organic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developed in an environmentally benign manner. In this reaction, the readily available CF3SO2Na was selected as the trifluoromethylation reagent. The in situ generated byproduct SO2 was reutilized to activate C-OH bond, which enabled this dehydroxylative trifluoromethylation to be performed conveniently. A variety of multifunctionalized CF3-allylic compounds were obtained in high yields and excellent stereoselectivity.

源语言	英语
页（从-至）	5235-5240
页数	6
期刊	Organic Letters
卷	23
期	13
DOI	https://doi.org/10.1021/acs.orglett.1c01767
出版状态	已出版 - 2 7月 2021
已对外发布	是

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abstract = "An organic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developed in an environmentally benign manner. In this reaction, the readily available CF3SO2Na was selected as the trifluoromethylation reagent. The in situ generated byproduct SO2 was reutilized to activate C-OH bond, which enabled this dehydroxylative trifluoromethylation to be performed conveniently. A variety of multifunctionalized CF3-allylic compounds were obtained in high yields and excellent stereoselectivity.",

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AU - Li, Bowen

AU - Zeng, Wubing

AU - Wang, Lin

AU - Geng, Zhishuai

AU - Loh, Teck Peng

AU - Xie, Peizhong

PY - 2021/7/2

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N2 - An organic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developed in an environmentally benign manner. In this reaction, the readily available CF3SO2Na was selected as the trifluoromethylation reagent. The in situ generated byproduct SO2 was reutilized to activate C-OH bond, which enabled this dehydroxylative trifluoromethylation to be performed conveniently. A variety of multifunctionalized CF3-allylic compounds were obtained in high yields and excellent stereoselectivity.

AB - An organic photoredox-catalyzed dehydroxylative trifluoromethylation of allylic alcohols was developed in an environmentally benign manner. In this reaction, the readily available CF3SO2Na was selected as the trifluoromethylation reagent. The in situ generated byproduct SO2 was reutilized to activate C-OH bond, which enabled this dehydroxylative trifluoromethylation to be performed conveniently. A variety of multifunctionalized CF3-allylic compounds were obtained in high yields and excellent stereoselectivity.

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JO - Organic Letters

JF - Organic Letters

IS - 13

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Visible-Light-Induced Trifluoromethylation of Allylic Alcohols

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