α-amination of aldehydes catalyzed by in situ generated hypoiodite

Jie Sheng Tian; Kang Wai Jeffrey Ng; Jiun Ru Wong; Teck Peng Loh

doi:10.1002/anie.201204215

α-amination of aldehydes catalyzed by in situ generated hypoiodite

Jie Sheng Tian, Kang Wai Jeffrey Ng, Jiun Ru Wong, Teck Peng Loh

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

The metal-free amination of different aldehydes is catalyzed by hypoiodite, which is generated by employing commercially available sodium percarbonate as the co-oxidant. This approach has several advantages: it is a metal-free oxidation that works under mild reaction conditions; furthermore, it has a wide substrate scope and does not give toxic by-products from the co-oxidant that is used.

Original language	English
Pages (from-to)	9105-9109
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	36
DOIs	https://doi.org/10.1002/anie.201204215
State	Published - 3 Sep 2012
Externally published	Yes

Keywords

aldehydes
amination
hypoiodite
sodium percarbonate
α-amino acetal

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10.1002/anie.201204215

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abstract = "The metal-free amination of different aldehydes is catalyzed by hypoiodite, which is generated by employing commercially available sodium percarbonate as the co-oxidant. This approach has several advantages: it is a metal-free oxidation that works under mild reaction conditions; furthermore, it has a wide substrate scope and does not give toxic by-products from the co-oxidant that is used.",

keywords = "aldehydes, amination, hypoiodite, sodium percarbonate, α-amino acetal",

author = "Tian, {Jie Sheng} and Ng, {Kang Wai Jeffrey} and Wong, {Jiun Ru} and Loh, {Teck Peng}",

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AU - Tian, Jie Sheng

AU - Ng, Kang Wai Jeffrey

AU - Wong, Jiun Ru

AU - Loh, Teck Peng

PY - 2012/9/3

Y1 - 2012/9/3

N2 - The metal-free amination of different aldehydes is catalyzed by hypoiodite, which is generated by employing commercially available sodium percarbonate as the co-oxidant. This approach has several advantages: it is a metal-free oxidation that works under mild reaction conditions; furthermore, it has a wide substrate scope and does not give toxic by-products from the co-oxidant that is used.

AB - The metal-free amination of different aldehydes is catalyzed by hypoiodite, which is generated by employing commercially available sodium percarbonate as the co-oxidant. This approach has several advantages: it is a metal-free oxidation that works under mild reaction conditions; furthermore, it has a wide substrate scope and does not give toxic by-products from the co-oxidant that is used.

KW - aldehydes

KW - amination

KW - hypoiodite

KW - sodium percarbonate

KW - α-amino acetal

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U2 - 10.1002/anie.201204215

DO - 10.1002/anie.201204215

M3 - 文章

AN - SCOPUS:84865847452

SN - 1433-7851

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 36

ER -

α-amination of aldehydes catalyzed by in situ generated hypoiodite

Abstract

Keywords

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