α-Amino Acetal: A Synthetic Intermediate for the Construction of Aza-Polycycles

Duan Yang Liu; Si Mao Zhu; Rui Qi Li; Jie Sheng Tian; Teck Peng Loh

doi:10.1021/acs.orglett.9b02240

α-Amino Acetal: A Synthetic Intermediate for the Construction of Aza-Polycycles

Duan Yang Liu, Si Mao Zhu, Rui Qi Li, Jie Sheng Tian, Teck Peng Loh

School of Chemistry and Moleculai Engineering

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

One-step construction of aza-polycyclic skeletons was realized through double cyclization of the oxocarbenium and carbocation intermediates generated from α-amino acetals, which were designed and synthesized by employing our α-amination protocol of aldehydes. A simple process, a broad substrate range, commercialized materials, and extensive applications demonstrated the generality and effectiveness of this method.

Original language	English
Pages (from-to)	6357-6360
Number of pages	4
Journal	Organic Letters
Volume	21
Issue number	16
DOIs	https://doi.org/10.1021/acs.orglett.9b02240
State	Published - 16 Aug 2019

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title = "α-Amino Acetal: A Synthetic Intermediate for the Construction of Aza-Polycycles",

abstract = "One-step construction of aza-polycyclic skeletons was realized through double cyclization of the oxocarbenium and carbocation intermediates generated from α-amino acetals, which were designed and synthesized by employing our α-amination protocol of aldehydes. A simple process, a broad substrate range, commercialized materials, and extensive applications demonstrated the generality and effectiveness of this method.",

author = "Liu, {Duan Yang} and Zhu, {Si Mao} and Li, {Rui Qi} and Tian, {Jie Sheng} and Loh, {Teck Peng}",

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T1 - α-Amino Acetal

T2 - A Synthetic Intermediate for the Construction of Aza-Polycycles

AU - Liu, Duan Yang

AU - Zhu, Si Mao

AU - Li, Rui Qi

AU - Tian, Jie Sheng

AU - Loh, Teck Peng

PY - 2019/8/16

Y1 - 2019/8/16

N2 - One-step construction of aza-polycyclic skeletons was realized through double cyclization of the oxocarbenium and carbocation intermediates generated from α-amino acetals, which were designed and synthesized by employing our α-amination protocol of aldehydes. A simple process, a broad substrate range, commercialized materials, and extensive applications demonstrated the generality and effectiveness of this method.

AB - One-step construction of aza-polycyclic skeletons was realized through double cyclization of the oxocarbenium and carbocation intermediates generated from α-amino acetals, which were designed and synthesized by employing our α-amination protocol of aldehydes. A simple process, a broad substrate range, commercialized materials, and extensive applications demonstrated the generality and effectiveness of this method.

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M3 - 文章

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AN - SCOPUS:85071355483

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ER -

α-Amino Acetal: A Synthetic Intermediate for the Construction of Aza-Polycycles

Abstract

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