A Cheap and Efficient Oxidant (n-Bu)4NNO3-Enabled C(sp2)- and C(sp3)-H Olefination at Room Temperature

Cheng Hao Gu; Zhen Zhang; Shuo Jie Shen; Hua Jin Xu; Yi Hu

doi:10.1021/acs.orglett.3c00621

A Cheap and Efficient Oxidant (n-Bu)₄NNO₃-Enabled C(sp²)- and C(sp³)-H Olefination at Room Temperature

Cheng Hao Gu, Zhen Zhang, Shuo Jie Shen, Hua Jin Xu, Yi Hu

School of Pharmaceutical Sciences

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

To further promote the widely practical application of C-H activation, developing green and mild reaction conditions has invariably been the objective of researchers, especially when it comes to remote C-H activation reactions. Herein, we report a new cheap and powerful (n-Bu)₄NNO₃ oxidant. This oxidant is efficient and universal for Pd(II)-catalyzed sp² and sp³ C-H olefination and allows the reaction to be carried out at room temperature. Because of this, we attempted to make C-H functionalization more economical and environmentally benign.

Original language	English
Pages (from-to)	2622-2626
Number of pages	5
Journal	Organic Letters
Volume	25
Issue number	15
DOIs	https://doi.org/10.1021/acs.orglett.3c00621
State	Published - 21 Apr 2023

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10.1021/acs.orglett.3c00621

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title = "A Cheap and Efficient Oxidant (n-Bu)4NNO3-Enabled C(sp2)- and C(sp3)-H Olefination at Room Temperature",

abstract = "To further promote the widely practical application of C-H activation, developing green and mild reaction conditions has invariably been the objective of researchers, especially when it comes to remote C-H activation reactions. Herein, we report a new cheap and powerful (n-Bu)4NNO3 oxidant. This oxidant is efficient and universal for Pd(II)-catalyzed sp2 and sp3 C-H olefination and allows the reaction to be carried out at room temperature. Because of this, we attempted to make C-H functionalization more economical and environmentally benign.",

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T1 - A Cheap and Efficient Oxidant (n-Bu)4NNO3-Enabled C(sp2)- and C(sp3)-H Olefination at Room Temperature

AU - Gu, Cheng Hao

AU - Zhang, Zhen

AU - Shen, Shuo Jie

AU - Xu, Hua Jin

AU - Hu, Yi

PY - 2023/4/21

Y1 - 2023/4/21

N2 - To further promote the widely practical application of C-H activation, developing green and mild reaction conditions has invariably been the objective of researchers, especially when it comes to remote C-H activation reactions. Herein, we report a new cheap and powerful (n-Bu)4NNO3 oxidant. This oxidant is efficient and universal for Pd(II)-catalyzed sp2 and sp3 C-H olefination and allows the reaction to be carried out at room temperature. Because of this, we attempted to make C-H functionalization more economical and environmentally benign.

AB - To further promote the widely practical application of C-H activation, developing green and mild reaction conditions has invariably been the objective of researchers, especially when it comes to remote C-H activation reactions. Herein, we report a new cheap and powerful (n-Bu)4NNO3 oxidant. This oxidant is efficient and universal for Pd(II)-catalyzed sp2 and sp3 C-H olefination and allows the reaction to be carried out at room temperature. Because of this, we attempted to make C-H functionalization more economical and environmentally benign.

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U2 - 10.1021/acs.orglett.3c00621

DO - 10.1021/acs.orglett.3c00621

M3 - 文章

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AN - SCOPUS:85153413194

SN - 1523-7060

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SP - 2622

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JO - Organic Letters

JF - Organic Letters

IS - 15

ER -

A Cheap and Efficient Oxidant (n-Bu)₄NNO₃-Enabled C(sp²)- and C(sp³)-H Olefination at Room Temperature

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