A simple oxazolidine linker for solid-phase synthesis of peptide aldehydes

Wu Kang; Weiguo Wang; Xiaoxia Zhi; Bo Zhang; Ping Wei; Hongyan Xu

doi:10.1016/j.bmcl.2011.11.081

A simple oxazolidine linker for solid-phase synthesis of peptide aldehydes

Wu Kang, Weiguo Wang, Xiaoxia Zhi, Bo Zhang, Ping Wei, Hongyan Xu

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A very simple and cheap linker has been used for solid-phase synthesis of peptide aldehydes. Protected amino acid aldehydes are immobilized on 2-Cl(trt) resin as oxazolidine formation via diethanolamine. After classical Fmoc SPPS, treatment of the resin with AcOH/DCM/H ₂O (8:1:1) affords peptide aldehydes in high yield and purity.

Original language	English
Pages (from-to)	1187-1188
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2011.11.081
State	Published - 15 Jan 2012

Keywords

2-Cl(trt) resin
Diethanolamine
Oxazolidine
Peptide aldehydes
Solid-phase synthesis

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10.1016/j.bmcl.2011.11.081

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title = "A simple oxazolidine linker for solid-phase synthesis of peptide aldehydes",

abstract = "A very simple and cheap linker has been used for solid-phase synthesis of peptide aldehydes. Protected amino acid aldehydes are immobilized on 2-Cl(trt) resin as oxazolidine formation via diethanolamine. After classical Fmoc SPPS, treatment of the resin with AcOH/DCM/H 2O (8:1:1) affords peptide aldehydes in high yield and purity.",

keywords = "2-Cl(trt) resin, Diethanolamine, Oxazolidine, Peptide aldehydes, Solid-phase synthesis",

author = "Wu Kang and Weiguo Wang and Xiaoxia Zhi and Bo Zhang and Ping Wei and Hongyan Xu",

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T1 - A simple oxazolidine linker for solid-phase synthesis of peptide aldehydes

AU - Kang, Wu

AU - Wang, Weiguo

AU - Zhi, Xiaoxia

AU - Zhang, Bo

AU - Wei, Ping

AU - Xu, Hongyan

PY - 2012/1/15

Y1 - 2012/1/15

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AB - A very simple and cheap linker has been used for solid-phase synthesis of peptide aldehydes. Protected amino acid aldehydes are immobilized on 2-Cl(trt) resin as oxazolidine formation via diethanolamine. After classical Fmoc SPPS, treatment of the resin with AcOH/DCM/H 2O (8:1:1) affords peptide aldehydes in high yield and purity.

KW - 2-Cl(trt) resin

KW - Diethanolamine

KW - Oxazolidine

KW - Peptide aldehydes

KW - Solid-phase synthesis

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DO - 10.1016/j.bmcl.2011.11.081

M3 - 文章

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AN - SCOPUS:84855701715

SN - 0960-894X

VL - 22

SP - 1187

EP - 1188

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

A simple oxazolidine linker for solid-phase synthesis of peptide aldehydes

Abstract

Keywords

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