Acyclic stereocontrol based on chelation-controlled ene reaction with chiral α- and β-alkoxyaldehydes

Koichi Mikami; Teck Peng Loh; Takeshi Nakai

doi:10.1016/S0957-4166(00)82265-X

Acyclic stereocontrol based on chelation-controlled ene reaction with chiral α- and β-alkoxyaldehydes

Koichi Mikami, Teck Peng Loh, Takeshi Nakai

Institute of Science Tokyo

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The Lewis acid-promoted ene reactions with chiral α- and β-benzyloxy aldehydes have been developed and shown to afford high levels of both diastereofacial (chelation) selection and simple diastereoselection (anti), thus providing an efficient method for stereocontrol over three contiguous chiral centers.

Original language	English
Pages (from-to)	13-16
Number of pages	4
Journal	Tetrahedron Asymmetry
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/S0957-4166(00)82265-X
State	Published - 1990
Externally published	Yes

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title = "Acyclic stereocontrol based on chelation-controlled ene reaction with chiral α- and β-alkoxyaldehydes",

abstract = "The Lewis acid-promoted ene reactions with chiral α- and β-benzyloxy aldehydes have been developed and shown to afford high levels of both diastereofacial (chelation) selection and simple diastereoselection (anti), thus providing an efficient method for stereocontrol over three contiguous chiral centers.",

author = "Koichi Mikami and Loh, {Teck Peng} and Takeshi Nakai",

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doi = "10.1016/S0957-4166(00)82265-X",

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T1 - Acyclic stereocontrol based on chelation-controlled ene reaction with chiral α- and β-alkoxyaldehydes

AU - Mikami, Koichi

AU - Loh, Teck Peng

AU - Nakai, Takeshi

PY - 1990

Y1 - 1990

N2 - The Lewis acid-promoted ene reactions with chiral α- and β-benzyloxy aldehydes have been developed and shown to afford high levels of both diastereofacial (chelation) selection and simple diastereoselection (anti), thus providing an efficient method for stereocontrol over three contiguous chiral centers.

AB - The Lewis acid-promoted ene reactions with chiral α- and β-benzyloxy aldehydes have been developed and shown to afford high levels of both diastereofacial (chelation) selection and simple diastereoselection (anti), thus providing an efficient method for stereocontrol over three contiguous chiral centers.

UR - http://www.scopus.com/inward/record.url?scp=0001771174&partnerID=8YFLogxK

U2 - 10.1016/S0957-4166(00)82265-X

DO - 10.1016/S0957-4166(00)82265-X

M3 - 文章

AN - SCOPUS:0001771174

SN - 0957-4166

VL - 1

SP - 13

EP - 16

JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 1

ER -

Acyclic stereocontrol based on chelation-controlled ene reaction with chiral α- and β-alkoxyaldehydes

Abstract

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