Biomineralized CO gas-releasing nanoprodrug for endoplasmic reticulum stress mediated cancer therapy

Rui Gu; Wanlan Yang; Lifei Han; Chao Liu; Yatao Xu; Yunlong Liu; Weili Si; Wenjun Wang; Xiaochen Dong

doi:10.1007/s12274-023-5458-8

Biomineralized CO gas-releasing nanoprodrug for endoplasmic reticulum stress mediated cancer therapy

Rui Gu, Wanlan Yang, Lifei Han, Chao Liu, Yatao Xu, Yunlong Liu, Weili Si, Wenjun Wang, Xiaochen Dong

SCHOOL OF FLEXIBLE ELECTRONICS(FUTURE TECHNOLOGIES)|INSTITUTE OF ADVANCED MATERIALS(IAM)

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The anti-tumor effect of therapeutic carbon monoxide (CO) has been considered concerning the electron transport chain on the inner mitochondrial membrane. Herein, a tumor microenvironment and photo-responsive CO nanoplatform Ca-Flav nanoparticles (NPs) were constructed through biomineralizing acryloyl-modified flavonol, which could release CO both in normoxia and hypoxia conditions upon irradiation at tumor lesion. The in vitro experiments demonstrated that the endoplasmic reticulum stress-related signal pathways could be activated through oxidative stress caused by CO mediated mitochondrial biogenesis and calcium ion turbulence induced by Ca₃(PO₄)₂ acidolysis, resulting in mitochondrial dysfunction and cell apoptosis. In addition, the Ca-Flav NPs exhibited excellent biocompatibility and tumor inhibition effect in vivo. This work provides new insight into the potential characteristics of CO, paving a new way to engineer more efficient treatment based on CO. [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	7373-7382
Number of pages	10
Journal	Nano Research
Volume	16
Issue number	5
DOIs	https://doi.org/10.1007/s12274-023-5458-8
State	Published - May 2023

Keywords

carbon monoxide
endoplasmic reticulum
gas therapy
mitochondrial

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12274-023-5458-8

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@article{53ff76f052fb42aebba720a8211533d8,

title = "Biomineralized CO gas-releasing nanoprodrug for endoplasmic reticulum stress mediated cancer therapy",

abstract = "The anti-tumor effect of therapeutic carbon monoxide (CO) has been considered concerning the electron transport chain on the inner mitochondrial membrane. Herein, a tumor microenvironment and photo-responsive CO nanoplatform Ca-Flav nanoparticles (NPs) were constructed through biomineralizing acryloyl-modified flavonol, which could release CO both in normoxia and hypoxia conditions upon irradiation at tumor lesion. The in vitro experiments demonstrated that the endoplasmic reticulum stress-related signal pathways could be activated through oxidative stress caused by CO mediated mitochondrial biogenesis and calcium ion turbulence induced by Ca3(PO4)2 acidolysis, resulting in mitochondrial dysfunction and cell apoptosis. In addition, the Ca-Flav NPs exhibited excellent biocompatibility and tumor inhibition effect in vivo. This work provides new insight into the potential characteristics of CO, paving a new way to engineer more efficient treatment based on CO. [Figure not available: see fulltext.]",

keywords = "carbon monoxide, endoplasmic reticulum, gas therapy, mitochondrial",

author = "Rui Gu and Wanlan Yang and Lifei Han and Chao Liu and Yatao Xu and Yunlong Liu and Weili Si and Wenjun Wang and Xiaochen Dong",

note = "Publisher Copyright: {\textcopyright} 2023, Tsinghua University Press.",

year = "2023",

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doi = "10.1007/s12274-023-5458-8",

language = "英语",

volume = "16",

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TY - JOUR

T1 - Biomineralized CO gas-releasing nanoprodrug for endoplasmic reticulum stress mediated cancer therapy

AU - Gu, Rui

AU - Yang, Wanlan

AU - Han, Lifei

AU - Liu, Chao

AU - Xu, Yatao

AU - Liu, Yunlong

AU - Si, Weili

AU - Wang, Wenjun

AU - Dong, Xiaochen

PY - 2023/5

Y1 - 2023/5

N2 - The anti-tumor effect of therapeutic carbon monoxide (CO) has been considered concerning the electron transport chain on the inner mitochondrial membrane. Herein, a tumor microenvironment and photo-responsive CO nanoplatform Ca-Flav nanoparticles (NPs) were constructed through biomineralizing acryloyl-modified flavonol, which could release CO both in normoxia and hypoxia conditions upon irradiation at tumor lesion. The in vitro experiments demonstrated that the endoplasmic reticulum stress-related signal pathways could be activated through oxidative stress caused by CO mediated mitochondrial biogenesis and calcium ion turbulence induced by Ca3(PO4)2 acidolysis, resulting in mitochondrial dysfunction and cell apoptosis. In addition, the Ca-Flav NPs exhibited excellent biocompatibility and tumor inhibition effect in vivo. This work provides new insight into the potential characteristics of CO, paving a new way to engineer more efficient treatment based on CO. [Figure not available: see fulltext.]

AB - The anti-tumor effect of therapeutic carbon monoxide (CO) has been considered concerning the electron transport chain on the inner mitochondrial membrane. Herein, a tumor microenvironment and photo-responsive CO nanoplatform Ca-Flav nanoparticles (NPs) were constructed through biomineralizing acryloyl-modified flavonol, which could release CO both in normoxia and hypoxia conditions upon irradiation at tumor lesion. The in vitro experiments demonstrated that the endoplasmic reticulum stress-related signal pathways could be activated through oxidative stress caused by CO mediated mitochondrial biogenesis and calcium ion turbulence induced by Ca3(PO4)2 acidolysis, resulting in mitochondrial dysfunction and cell apoptosis. In addition, the Ca-Flav NPs exhibited excellent biocompatibility and tumor inhibition effect in vivo. This work provides new insight into the potential characteristics of CO, paving a new way to engineer more efficient treatment based on CO. [Figure not available: see fulltext.]

KW - carbon monoxide

KW - endoplasmic reticulum

KW - gas therapy

KW - mitochondrial

UR - http://www.scopus.com/inward/record.url?scp=85146613960&partnerID=8YFLogxK

U2 - 10.1007/s12274-023-5458-8

DO - 10.1007/s12274-023-5458-8

M3 - 文章

AN - SCOPUS:85146613960

SN - 1998-0124

VL - 16

SP - 7373

EP - 7382

JO - Nano Research

JF - Nano Research

IS - 5

ER -

Biomineralized CO gas-releasing nanoprodrug for endoplasmic reticulum stress mediated cancer therapy

Abstract

Keywords

UN SDGs

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