Abstract
A novel calcium-catalyzed in situ dehydrative cross-coupling reaction of propargylic alcohols with 1,3-dicarbonyl compounds was developed. This catalytic system can suppress the competitive Meyer-Schuster rearrangement, control regioselectivity, and enable the desired process to occur under solvent-free conditions at room temperature with water as the only byproduct. A variety of vicinal tertiary and all-carbon quaternary centers can be obtained in high yields with broad functional group tolerance.
| Original language | English |
|---|---|
| Pages (from-to) | 5207-5211 |
| Number of pages | 5 |
| Journal | Green Chemistry |
| Volume | 21 |
| Issue number | 19 |
| DOIs | |
| State | Published - 2019 |