Cascade alkylation and deuteration with aryl iodides: Via Pd/norbornene catalysis: An efficient method for the synthesis of congested deuterium-labeled arenes

Lei Guo, Chen Xu, Ding Chuan Wu, Guang Qi Hu, Hong Hai Zhang, Kunlun Hong, Su Chen, Xiang Liu

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

An efficient approach for synthesizing congested deuterium-labeled arenes via cascade alkylation and deuteration with aryl iodides has been disclosed. We found that the adoption of sodium formate-d as a deuterium source is the key for achieving high deuterium incorporation >98%.

Original languageEnglish
Pages (from-to)8567-8570
Number of pages4
JournalChemical Communications
Volume55
Issue number59
DOIs
StatePublished - 2019

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