Catalytic asymmetric [4+2] annulation initiated by an aza-rauhut-currier reaction: Facile entry to highly functionalized tetrahydropyridines

Zugui Shi; Peiyuan Yu; Teck Peng Loh; Guofu Zhong

doi:10.1002/anie.201203316

Catalytic asymmetric [4+2] annulation initiated by an aza-rauhut-currier reaction: Facile entry to highly functionalized tetrahydropyridines

Zugui Shi, Peiyuan Yu, Teck Peng Loh, Guofu Zhong

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Under control: The first example of chiral amino phosphine catalysts for the title reaction between vinyl ketones and N-sulfonyl-1-aza-1,3-dienes has been developed. Under ambient conditions, this protocol provides straightforward access to densely functionalized, enantioenriched tetrahydropyridines with high levels of sterecontrol in good to excellent yields.

Original language	English
Pages (from-to)	7825-7829
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	31
DOIs	https://doi.org/10.1002/anie.201203316
State	Published - 27 Jul 2012
Externally published	Yes

Keywords

annulation
asymmetric catalysis
heterocycles
ketones
synthetic methods

Access to Document

10.1002/anie.201203316

Cite this

@article{0481359aa9fc4a9d8162846c8732fdf4,

title = "Catalytic asymmetric [4+2] annulation initiated by an aza-rauhut-currier reaction: Facile entry to highly functionalized tetrahydropyridines",

abstract = "Under control: The first example of chiral amino phosphine catalysts for the title reaction between vinyl ketones and N-sulfonyl-1-aza-1,3-dienes has been developed. Under ambient conditions, this protocol provides straightforward access to densely functionalized, enantioenriched tetrahydropyridines with high levels of sterecontrol in good to excellent yields.",

keywords = "annulation, asymmetric catalysis, heterocycles, ketones, synthetic methods",

author = "Zugui Shi and Peiyuan Yu and Loh, {Teck Peng} and Guofu Zhong",

year = "2012",

month = jul,

day = "27",

doi = "10.1002/anie.201203316",

language = "英语",

volume = "51",

pages = "7825--7829",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "31",

}

TY - JOUR

T1 - Catalytic asymmetric [4+2] annulation initiated by an aza-rauhut-currier reaction

T2 - Facile entry to highly functionalized tetrahydropyridines

AU - Shi, Zugui

AU - Yu, Peiyuan

AU - Loh, Teck Peng

AU - Zhong, Guofu

PY - 2012/7/27

Y1 - 2012/7/27

N2 - Under control: The first example of chiral amino phosphine catalysts for the title reaction between vinyl ketones and N-sulfonyl-1-aza-1,3-dienes has been developed. Under ambient conditions, this protocol provides straightforward access to densely functionalized, enantioenriched tetrahydropyridines with high levels of sterecontrol in good to excellent yields.

AB - Under control: The first example of chiral amino phosphine catalysts for the title reaction between vinyl ketones and N-sulfonyl-1-aza-1,3-dienes has been developed. Under ambient conditions, this protocol provides straightforward access to densely functionalized, enantioenriched tetrahydropyridines with high levels of sterecontrol in good to excellent yields.

KW - annulation

KW - asymmetric catalysis

KW - heterocycles

KW - ketones

KW - synthetic methods

UR - http://www.scopus.com/inward/record.url?scp=84864414308&partnerID=8YFLogxK

U2 - 10.1002/anie.201203316

DO - 10.1002/anie.201203316

M3 - 文章

C2 - 22833412

AN - SCOPUS:84864414308

SN - 1433-7851

VL - 51

SP - 7825

EP - 7829

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 31

ER -

Catalytic asymmetric [4+2] annulation initiated by an aza-rauhut-currier reaction: Facile entry to highly functionalized tetrahydropyridines

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this