Cobalt-Catalyzed Carbonylative Synthesis of 4-Oxobutanoates from Formamide and Ethylene

Le Cheng Wang; Nai Xian Sun; Chang Sheng Wang; Kai Guo; Xiao Feng Wu

doi:10.1021/acs.orglett.3c02973

Cobalt-Catalyzed Carbonylative Synthesis of 4-Oxobutanoates from Formamide and Ethylene

Le Cheng Wang, Nai Xian Sun, Chang Sheng Wang, Kai Guo, Xiao Feng Wu

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The direct concurrent installation of amide and ester groups across olefin motifs represents a powerful and promising functionalization tool in organic chemistry. Herein, a ligand-free cobalt-catalyzed four-component radical relay carbonylative difunctionalization of ethylene for the synthesis of 4-oxobutanoates has been developed. Valuable C4 building blocks were produced in a highly atom-economical fashion.

Original language	English
Pages (from-to)	7417-7421
Number of pages	5
Journal	Organic Letters
Volume	25
Issue number	40
DOIs	https://doi.org/10.1021/acs.orglett.3c02973
State	Published - 13 Oct 2023

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abstract = "The direct concurrent installation of amide and ester groups across olefin motifs represents a powerful and promising functionalization tool in organic chemistry. Herein, a ligand-free cobalt-catalyzed four-component radical relay carbonylative difunctionalization of ethylene for the synthesis of 4-oxobutanoates has been developed. Valuable C4 building blocks were produced in a highly atom-economical fashion.",

author = "Wang, {Le Cheng} and Sun, {Nai Xian} and Wang, {Chang Sheng} and Kai Guo and Wu, {Xiao Feng}",

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T1 - Cobalt-Catalyzed Carbonylative Synthesis of 4-Oxobutanoates from Formamide and Ethylene

AU - Wang, Le Cheng

AU - Sun, Nai Xian

AU - Wang, Chang Sheng

AU - Guo, Kai

AU - Wu, Xiao Feng

PY - 2023/10/13

Y1 - 2023/10/13

N2 - The direct concurrent installation of amide and ester groups across olefin motifs represents a powerful and promising functionalization tool in organic chemistry. Herein, a ligand-free cobalt-catalyzed four-component radical relay carbonylative difunctionalization of ethylene for the synthesis of 4-oxobutanoates has been developed. Valuable C4 building blocks were produced in a highly atom-economical fashion.

AB - The direct concurrent installation of amide and ester groups across olefin motifs represents a powerful and promising functionalization tool in organic chemistry. Herein, a ligand-free cobalt-catalyzed four-component radical relay carbonylative difunctionalization of ethylene for the synthesis of 4-oxobutanoates has been developed. Valuable C4 building blocks were produced in a highly atom-economical fashion.

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U2 - 10.1021/acs.orglett.3c02973

DO - 10.1021/acs.orglett.3c02973

M3 - 文章

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AN - SCOPUS:85175587359

SN - 1523-7060

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SP - 7417

EP - 7421

JO - Organic Letters

JF - Organic Letters

IS - 40

ER -

Cobalt-Catalyzed Carbonylative Synthesis of 4-Oxobutanoates from Formamide and Ethylene

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