Cobalt-catalyzed cross-coupling of lithium (hetero)aryl zincates with heteroaryl chlorides and bromides

Shuanshuan Liu; Weichen Huang; Decai Wang; Ping Wei; Qilong Shen

doi:10.1039/c9qo00551j

Cobalt-catalyzed cross-coupling of lithium (hetero)aryl zincates with heteroaryl chlorides and bromides

Shuanshuan Liu, Weichen Huang, Decai Wang, Ping Wei, Qilong Shen

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A mild, efficient and practical Co-catalyzed cross coupling reaction of a variety of activated heteroaryl chlorides and bromides with lithium aryl zincates that were in situ generated from lithium aryl boronates with ZnBr₂ was described. The substrate scope was broad and the reaction conditions were mild and tolerant of various base sensitive functional groups such as esters, enolizable ketones and aldehydes.

Original language	English
Pages (from-to)	2630-2634
Number of pages	5
Journal	Organic Chemistry Frontiers
Volume	6
Issue number	15
DOIs	https://doi.org/10.1039/c9qo00551j
State	Published - 7 Aug 2019

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title = "Cobalt-catalyzed cross-coupling of lithium (hetero)aryl zincates with heteroaryl chlorides and bromides",

abstract = "A mild, efficient and practical Co-catalyzed cross coupling reaction of a variety of activated heteroaryl chlorides and bromides with lithium aryl zincates that were in situ generated from lithium aryl boronates with ZnBr2 was described. The substrate scope was broad and the reaction conditions were mild and tolerant of various base sensitive functional groups such as esters, enolizable ketones and aldehydes.",

author = "Shuanshuan Liu and Weichen Huang and Decai Wang and Ping Wei and Qilong Shen",

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AU - Liu, Shuanshuan

AU - Huang, Weichen

AU - Wang, Decai

AU - Wei, Ping

AU - Shen, Qilong

PY - 2019/8/7

Y1 - 2019/8/7

N2 - A mild, efficient and practical Co-catalyzed cross coupling reaction of a variety of activated heteroaryl chlorides and bromides with lithium aryl zincates that were in situ generated from lithium aryl boronates with ZnBr2 was described. The substrate scope was broad and the reaction conditions were mild and tolerant of various base sensitive functional groups such as esters, enolizable ketones and aldehydes.

AB - A mild, efficient and practical Co-catalyzed cross coupling reaction of a variety of activated heteroaryl chlorides and bromides with lithium aryl zincates that were in situ generated from lithium aryl boronates with ZnBr2 was described. The substrate scope was broad and the reaction conditions were mild and tolerant of various base sensitive functional groups such as esters, enolizable ketones and aldehydes.

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M3 - 文章

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SN - 2052-4110

VL - 6

SP - 2630

EP - 2634

JO - Organic Chemistry Frontiers

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ER -

Cobalt-catalyzed cross-coupling of lithium (hetero)aryl zincates with heteroaryl chlorides and bromides

Abstract

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