Cobalt-Catalyzed Hydroxymethylation of Alkyl Halides with CO as the C1 Source

Yang Yuan; Nai Xian Sun; Chang Sheng Wang; Kai Guo; Xiao Feng Wu

doi:10.1021/acs.orglett.3c01811

Cobalt-Catalyzed Hydroxymethylation of Alkyl Halides with CO as the C1 Source

Yang Yuan, Nai Xian Sun, Chang Sheng Wang, Kai Guo, Xiao Feng Wu

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Research output: Contribution to journal › Article › peer-review

Abstract

Herein, we developed an effective strategy for the synthesis of one-carbon-extended alcohols through cobalt-catalyzed hydroxymethylation of alkyl halides with carbon monoxide as the C1 source and cheap and environmentally friendly PMHS as the hydride source. This procedure also features a ligand-free cobalt catalyst and a broad range of functional group tolerance.

Original language	English
Pages (from-to)	5084-5088
Number of pages	5
Journal	Organic Letters
Volume	25
Issue number	27
DOIs	https://doi.org/10.1021/acs.orglett.3c01811
State	Published - 14 Jul 2023

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title = "Cobalt-Catalyzed Hydroxymethylation of Alkyl Halides with CO as the C1 Source",

abstract = "Herein, we developed an effective strategy for the synthesis of one-carbon-extended alcohols through cobalt-catalyzed hydroxymethylation of alkyl halides with carbon monoxide as the C1 source and cheap and environmentally friendly PMHS as the hydride source. This procedure also features a ligand-free cobalt catalyst and a broad range of functional group tolerance.",

author = "Yang Yuan and Sun, {Nai Xian} and Wang, {Chang Sheng} and Kai Guo and Wu, {Xiao Feng}",

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doi = "10.1021/acs.orglett.3c01811",

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T1 - Cobalt-Catalyzed Hydroxymethylation of Alkyl Halides with CO as the C1 Source

AU - Yuan, Yang

AU - Sun, Nai Xian

AU - Wang, Chang Sheng

AU - Guo, Kai

AU - Wu, Xiao Feng

PY - 2023/7/14

Y1 - 2023/7/14

N2 - Herein, we developed an effective strategy for the synthesis of one-carbon-extended alcohols through cobalt-catalyzed hydroxymethylation of alkyl halides with carbon monoxide as the C1 source and cheap and environmentally friendly PMHS as the hydride source. This procedure also features a ligand-free cobalt catalyst and a broad range of functional group tolerance.

AB - Herein, we developed an effective strategy for the synthesis of one-carbon-extended alcohols through cobalt-catalyzed hydroxymethylation of alkyl halides with carbon monoxide as the C1 source and cheap and environmentally friendly PMHS as the hydride source. This procedure also features a ligand-free cobalt catalyst and a broad range of functional group tolerance.

UR - http://www.scopus.com/inward/record.url?scp=85164789775&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.3c01811

DO - 10.1021/acs.orglett.3c01811

M3 - 文章

C2 - 37382494

AN - SCOPUS:85164789775

SN - 1523-7060

VL - 25

SP - 5084

EP - 5088

JO - Organic Letters

JF - Organic Letters

IS - 27

ER -

Cobalt-Catalyzed Hydroxymethylation of Alkyl Halides with CO as the C1 Source

Abstract

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