Colorimetric and fluorometric detection of neomycin based on conjugated polydiacetylene supramolecules

Guodong Zhou; Fang Wang; Huilin Wang; Srinivasulu Kambam; Xiaoqiang Chen

doi:10.1002/marc.201200837

Colorimetric and fluorometric detection of neomycin based on conjugated polydiacetylene supramolecules

Guodong Zhou, Fang Wang, Huilin Wang, Srinivasulu Kambam, Xiaoqiang Chen

College of Chemical Engineering

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Utilizing the colorimetric and fluorogenic changes, a system based on polydiacetylenes (PDAs) is developed for the detection of neomycin. The PDA supramolecules polymerized from the mixed liposome composed of N-(3-hydroxyphenyl)pentacosa-10,12-diynamide (PCDA-AP) and pentacosa-10,12- diynoic acid (PCDA) at an optimized ratio of 1:9 display a unique colorimetric change (blue to red) and fluorescent enhancement in the presence of neomycin. The detection limit for neomycin is estimated to be 2.55 × 10^-7 M by the fluorogenic method. The optical changes induced by neomycin can be attributed to the disruption of the hydrogen bonding between phenol and carboxylic acid from PCDA-AP and PCDA. Polydiacetylene supramolecules polymerized from a mixed liposome composed of N-(3-hydroxyphenyl)pentacosa-10, 12-diynamide and pentacosa-10,12-diynoic acid at an optimal ratio of 1:9 display a unique colorimetric change (blue to red) and fluorescent enhancement in the presence of neomycin.

Original language	English
Pages (from-to)	944-948
Number of pages	5
Journal	Macromolecular Rapid Communications
Volume	34
Issue number	11
DOIs	https://doi.org/10.1002/marc.201200837
State	Published - 13 Jun 2013

Keywords

colorimetric change
fluorescent sensors
neomycin
polydiacetylene supramolecules

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title = "Colorimetric and fluorometric detection of neomycin based on conjugated polydiacetylene supramolecules",

abstract = "Utilizing the colorimetric and fluorogenic changes, a system based on polydiacetylenes (PDAs) is developed for the detection of neomycin. The PDA supramolecules polymerized from the mixed liposome composed of N-(3-hydroxyphenyl)pentacosa-10,12-diynamide (PCDA-AP) and pentacosa-10,12- diynoic acid (PCDA) at an optimized ratio of 1:9 display a unique colorimetric change (blue to red) and fluorescent enhancement in the presence of neomycin. The detection limit for neomycin is estimated to be 2.55 × 10-7 M by the fluorogenic method. The optical changes induced by neomycin can be attributed to the disruption of the hydrogen bonding between phenol and carboxylic acid from PCDA-AP and PCDA. Polydiacetylene supramolecules polymerized from a mixed liposome composed of N-(3-hydroxyphenyl)pentacosa-10, 12-diynamide and pentacosa-10,12-diynoic acid at an optimal ratio of 1:9 display a unique colorimetric change (blue to red) and fluorescent enhancement in the presence of neomycin.",

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author = "Guodong Zhou and Fang Wang and Huilin Wang and Srinivasulu Kambam and Xiaoqiang Chen",

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AU - Zhou, Guodong

AU - Wang, Fang

AU - Wang, Huilin

AU - Kambam, Srinivasulu

AU - Chen, Xiaoqiang

PY - 2013/6/13

Y1 - 2013/6/13

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AB - Utilizing the colorimetric and fluorogenic changes, a system based on polydiacetylenes (PDAs) is developed for the detection of neomycin. The PDA supramolecules polymerized from the mixed liposome composed of N-(3-hydroxyphenyl)pentacosa-10,12-diynamide (PCDA-AP) and pentacosa-10,12- diynoic acid (PCDA) at an optimized ratio of 1:9 display a unique colorimetric change (blue to red) and fluorescent enhancement in the presence of neomycin. The detection limit for neomycin is estimated to be 2.55 × 10-7 M by the fluorogenic method. The optical changes induced by neomycin can be attributed to the disruption of the hydrogen bonding between phenol and carboxylic acid from PCDA-AP and PCDA. Polydiacetylene supramolecules polymerized from a mixed liposome composed of N-(3-hydroxyphenyl)pentacosa-10, 12-diynamide and pentacosa-10,12-diynoic acid at an optimal ratio of 1:9 display a unique colorimetric change (blue to red) and fluorescent enhancement in the presence of neomycin.

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Colorimetric and fluorometric detection of neomycin based on conjugated polydiacetylene supramolecules

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