Continuous Electrochemical Synthesis of Iso-Coumarin Derivatives from o-(1-Alkynyl) Benzoates under Metal- and Oxidant-Free

Xinxin Lin; Zheng Fang; Cuilian Zeng; Chenlong Zhu; Xinyan Pang; Chengkou Liu; Wei He; Jindian Duan; Ning Qin; Kai Guo

doi:10.1002/chem.202001766

Continuous Electrochemical Synthesis of Iso-Coumarin Derivatives from o-(1-Alkynyl) Benzoates under Metal- and Oxidant-Free

Xinxin Lin, Zheng Fang, Cuilian Zeng, Chenlong Zhu, Xinyan Pang, Chengkou Liu, Wei He, Jindian Duan, Ning Qin, Kai Guo

COLLEGE OF BIOTECHNOLOGY AND PHARMACEUTICAL ENGINEERING

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

A non-oxidant and metal-free strategy for synthesizing iso-coumarin by using a continuous electrochemical microreactor to initiate an oxidative cyclization reaction of o-(1-alkynyl) benzoate and radicals. This efficient and clean continuous electrosynthesis method not only avoids the complicated gas protection operation and production of by-products in the batch processes, but also help to overcome the difficulty that batch metal catalysis and electrocatalysis are difficult to scale up, and has the potential for pilot-scale experiment.

Original language	English
Pages (from-to)	13738-13742
Number of pages	5
Journal	Chemistry - A European Journal
Volume	26
Issue number	60
DOIs	https://doi.org/10.1002/chem.202001766
State	Published - 27 Oct 2020

Keywords

cyclization
electrochemistry
iso-coumarin
microreactor

Access to Document

10.1002/chem.202001766

Cite this

@article{0a8e21d397eb47ada00438793915ed40,

title = "Continuous Electrochemical Synthesis of Iso-Coumarin Derivatives from o-(1-Alkynyl) Benzoates under Metal- and Oxidant-Free",

abstract = "A non-oxidant and metal-free strategy for synthesizing iso-coumarin by using a continuous electrochemical microreactor to initiate an oxidative cyclization reaction of o-(1-alkynyl) benzoate and radicals. This efficient and clean continuous electrosynthesis method not only avoids the complicated gas protection operation and production of by-products in the batch processes, but also help to overcome the difficulty that batch metal catalysis and electrocatalysis are difficult to scale up, and has the potential for pilot-scale experiment.",

keywords = "cyclization, electrochemistry, iso-coumarin, microreactor",

author = "Xinxin Lin and Zheng Fang and Cuilian Zeng and Chenlong Zhu and Xinyan Pang and Chengkou Liu and Wei He and Jindian Duan and Ning Qin and Kai Guo",

note = "Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH",

year = "2020",

month = oct,

day = "27",

doi = "10.1002/chem.202001766",

language = "英语",

volume = "26",

pages = "13738--13742",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "Wiley-VCH Verlag",

number = "60",

}

TY - JOUR

T1 - Continuous Electrochemical Synthesis of Iso-Coumarin Derivatives from o-(1-Alkynyl) Benzoates under Metal- and Oxidant-Free

AU - Lin, Xinxin

AU - Fang, Zheng

AU - Zeng, Cuilian

AU - Zhu, Chenlong

AU - Pang, Xinyan

AU - Liu, Chengkou

AU - He, Wei

AU - Duan, Jindian

AU - Qin, Ning

AU - Guo, Kai

PY - 2020/10/27

Y1 - 2020/10/27

N2 - A non-oxidant and metal-free strategy for synthesizing iso-coumarin by using a continuous electrochemical microreactor to initiate an oxidative cyclization reaction of o-(1-alkynyl) benzoate and radicals. This efficient and clean continuous electrosynthesis method not only avoids the complicated gas protection operation and production of by-products in the batch processes, but also help to overcome the difficulty that batch metal catalysis and electrocatalysis are difficult to scale up, and has the potential for pilot-scale experiment.

AB - A non-oxidant and metal-free strategy for synthesizing iso-coumarin by using a continuous electrochemical microreactor to initiate an oxidative cyclization reaction of o-(1-alkynyl) benzoate and radicals. This efficient and clean continuous electrosynthesis method not only avoids the complicated gas protection operation and production of by-products in the batch processes, but also help to overcome the difficulty that batch metal catalysis and electrocatalysis are difficult to scale up, and has the potential for pilot-scale experiment.

KW - cyclization

KW - electrochemistry

KW - iso-coumarin

KW - microreactor

UR - http://www.scopus.com/inward/record.url?scp=85091607640&partnerID=8YFLogxK

U2 - 10.1002/chem.202001766

DO - 10.1002/chem.202001766

M3 - 文章

C2 - 32460407

AN - SCOPUS:85091607640

SN - 0947-6539

VL - 26

SP - 13738

EP - 13742

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 60

ER -

Continuous Electrochemical Synthesis of Iso-Coumarin Derivatives from o-(1-Alkynyl) Benzoates under Metal- and Oxidant-Free

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this